Clinical therapeutic trial of aspirin and azapropazone in rheumatoid arthritis when prescribed singly and in combination

Current Medical Research and Opinion
W F KeanH A Capell

Abstract

A double-blind, crossover trial was carried out to assess the clinical efficacy of 3.6 g aspirin, 1200 mg azapropazone and the two drugs together in 24 adult patients with classical or definite rheumatoid disease. Pain score, morning stiffness and patients' assessment of pain were significantly improved for each drug regimen when compared to placebo. There was no significant difference among the individual drug regimens. Azapropazone was the best drug regimen in terms of improving pain score, morning stiffness and patient assessment of pain, but this was not statistically significant. It is concluded that there is no justification for prescribing aspirin with azapropazone in patients with rheumatoid disease.

References

Jan 1, 1977·Current Medical Research and Opinion·P M Brooks, T K Khong
Nov 1, 1979·British Journal of Clinical Pharmacology·D M GrennanM Mackinnon
Jul 1, 1976·Arthritis and Rheumatism·R F Willkens, E J Segre
Jul 12, 1975·British Medical Journal·P M BrooksA R Rhymer
Jan 1, 1972·Seminars in Arthritis and Rheumatism·W C Dick
Jan 1, 1974·Scandinavian Journal of Rheumatology·P LeeJ Webb
Jan 1, 1973·Scandinavian Journal of Rheumatology·J WebbP Lee
Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN

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