PMID: 11897969Mar 19, 2002Paper

Clinical toxicologic implications of ethylene glycol and glycolic acid poisoning

Therapeutic Drug Monitoring
A D Fraser

Abstract

Metabolic pathways have been elucidated for various chemical and solvent exposures in humans. Clinical laboratory analyses in most chemical and solvent exposures are directed toward identification and quantitation of unchanged substance in serum or whole blood. For example, most laboratories routinely screen for unchanged ethylene glycol in suspected poisonings and quantitate ethylene glycol in positive cases even though toxicity from ethylene glycol exposure (including central nervous system depression, acute renal failure, and elevated anion gap metabolic acidosis) is primarily caused by one metabolite-glycolic acid. One objective of this manuscript is to describe the authors' clinical experience with glycolic acid analysis in ethylene glycol human poisonings. Recommended clinical laboratory tests for small hospitals and toxicology reference laboratories are presented to rule out or confirm ethylene glycol exposure. Another concern with laboratory support in ethylene glycol poisoning is correct identification of ethylene glycol because analysis of this substance is often problematic. In one case laboratories incorrectly identified an organic acid from an inherited metabolic disease as ethylene glycol, and in another case the ...Continue Reading

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Citations

Sep 3, 2013·Current Pain and Headache Reports·Jérémy FerrierDavid Balayssac
Sep 5, 2014·Journal of Analytical Toxicology·Laurent ImbertChristian Lacroix
Sep 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jen-Hung YangJing-Gung Chung
Apr 23, 2013·The Journal of Emergency Medicine·Michael A Darracq, F Lee Cantrell
May 30, 2017·BMJ Case Reports·Jaya Prakash SugunarajIon Dan Bucaloiu
Mar 12, 2018·BMJ Case Reports·A S SagarBrandy J Mckelvy
Apr 28, 2005·American Journal of Physiology. Renal Physiology·Mike L GreenRobert W Freel
Feb 27, 2009·American Journal of Physiology. Renal Physiology·Yan Li, Kenneth E McMartin
Nov 23, 2013·Therapeutic Drug Monitoring·Sally L Hanton, Ian D Watson
Sep 6, 2015·Annals of Clinical Biochemistry·Loretta T Ford, Jonathan D Berg
Dec 14, 2018·Journal of Health & Pollution·Ajoke F Idayat Apanpa-Qasim, Adebola A Adeyi
Sep 6, 2020·Nutrients·Matteo BargagliPietro Manuel Ferraro
Apr 17, 2003·Transplantation·Mariano S Dy-LiaccoPaul C Kuo

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