Clinical trajectories in the ultra-high risk for psychosis population

Schizophrenia Research
Andrea PolariB Nelson

Abstract

Traditionally, research in the ultra-high risk (UHR) for psychosis population has focused on the treatment of existing symptomatology and prevention of transition to psychosis. Recently, there has been an increase in focus on outcomes in individuals who do not transition to psychosis. However, there is a lack of standardised definitions of remission, recovery, recurrence and relapse in UHR, resulting in the inability to generalise and replicate outcomes. The aims of the current study were to develop definitions for remission, recovery, recurrence and relapse, and apply them to a UHR cohort allowing the identification of longitudinal clinical trajectories. Further stratification in broader categories of favourable and unfavourable outcomes was applied. The predictive value of various baseline factors on specific clinical trajectories was also assessed. 17 different trajectories were identified in a cohort of 202 individuals within a 12-month period and classified according to the suggested definitions for recovery (35.7%), remission (7.5%), any recurrence (20%), no remission (17.3%), relapse (4.0%) and transition to psychosis (15.8%). Favourable and unfavourable trajectories represented 43.2% and 57.1% respectively. Long duratio...Continue Reading

Citations

Oct 26, 2018·Evidence-based Mental Health·Patrick D McGorry, Cristina Mei
Feb 19, 2020·Molecular Psychiatry·Christina Andreou, Stefan Borgwardt
May 27, 2020·Early Intervention in Psychiatry·Clément DondéJerome Brunelin
Sep 15, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Ana CatalanPaolo Fusar-Poli
Oct 31, 2019·BMC Psychiatry·Juan F Rodríguez-TestalCristina Senín-Calderón
Jun 20, 2020·Early Intervention in Psychiatry·Andrea PolariBarnaby Nelson
Apr 23, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Felipe ArgoloRodrigo A Bressan
Jul 24, 2021·Early Intervention in Psychiatry·Anna MeneghelliMauro Percudani
Nov 17, 2021·European Archives of Psychiatry and Clinical Neuroscience·Tor Gunnar VærnesPaul Møller

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