Clinical translation of controlled protein delivery systems for tissue engineering

Drug Delivery and Translational Research
Kara L Spiller, Gordana Vunjak-Novakovic

Abstract

Strategies that utilize controlled release of drugs and proteins for tissue engineering have enormous potential to regenerate damaged organs and tissues. The multiple advantages of controlled release strategies merit overcoming the significant challenges to translation, including high costs and long, difficult regulatory pathways. This review highlights the potential of controlled release of proteins for tissue engineering and regenerative medicine. We specifically discuss treatment modalities that have reached preclinical and clinical trials, with emphasis on controlled release systems for bone tissue engineering, the most advanced application with several products already in clinic. Possible strategies to address translational and regulatory concerns are also discussed.

References

Sep 1, 1991·Biomaterials·E R EdelmanM Klagsbrun
Sep 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M L BattenL E Dahners
Jun 24, 1999·Journal of Biomedical Materials Research·H UludagJ Wozney
Aug 25, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A J NixonH Mohammed
Aug 27, 1999·The Journal of Bone and Joint Surgery. British Volume·R G GeesinkS K Bulstra
Jan 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jue-Yeon LeeSeung-Jin Lee
Jan 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B ObradovicG Vunjak-Novakovic
Jan 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J ElisseeffR Langer
Apr 2, 2002·The Journal of Bone and Joint Surgery. British Volume·L A FortierA J Nixon
Jul 2, 2002·The Journal of Thoracic and Cardiovascular Surgery·Marc RuelFrank W Sellke
Jul 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·John StreetEllen H Filvaroff
Dec 11, 2002·The Journal of Bone and Joint Surgery. American Volume·Shunmugam GovenderUNKNOWN BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group
Mar 19, 2003·Circulation·Timothy D HenryUNKNOWN VIVA Investigators
Apr 18, 2003·Biomaterials·Goki MatsumuraToshiharu Shin'oka
Apr 22, 2003·Nature Biotechnology·Matthias P LutolfJeffrey A Hubbell
Aug 9, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Alexander R VaccaroTodd J Albert
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Theresa A HollandAntonios G Mikos
Sep 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jayanth PanyamVinod Labhasetwar
Oct 18, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andreas H ZischJeffrey A Hubbell
Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Theresa A HollandAntonios G Mikos
Mar 30, 2005·Circulation·Michael Simons
Jun 3, 2005·The Journal of Bone and Joint Surgery. American Volume·J Kenneth BurkusMichael C Longley
Jun 9, 2005·The Journal of Thoracic and Cardiovascular Surgery·Toshiharu Shin'okaHiromi Kurosawa
Jul 30, 2005·Journal of Biomedical Materials Research. Part a·Theresa A HollandJohn A Jansen
Oct 20, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hairong PengJohnny Huard
Jun 8, 2006·The Journal of Bone and Joint Surgery. American Volume·Marc F SwiontkowskiAmratlal Patel
Jun 10, 2006·Advanced Drug Delivery Reviews·Jiyoung M Dang, Kam W Leong

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Citations

Mar 5, 2014·Biomaterials·Kara L SpillerGordana Vunjak-Novakovic
Mar 8, 2016·Bone·Florence LoiStuart B Goodman
Jun 3, 2015·Advanced Healthcare Materials·Madhumita PatelByeongmoon Jeong
Oct 22, 2014·Annals of Biomedical Engineering·Kara L SpillerGordana Vunjak-Novakovic
Dec 4, 2016·Tissue Engineering. Part B, Reviews·Johnathan NgGordana Vunjak-Novakovic
Sep 12, 2020·Advanced Materials·Saber Amin YavariMichiel Croes
Dec 1, 2016·Nature Reviews. Materials·Jianyu Li, David J Mooney
Nov 24, 2020·Journal of Inflammation Research·Stuart B Goodman, Masahiro Maruyama
Jan 23, 2021·International Journal of Molecular Sciences·Érica Resende OliveiraAmin Shavandi
Jul 27, 2021·Frontiers in Chemistry·Subhash ChanderHarsha Kharkwal
Jan 16, 2021·ACS Biomaterials Science & Engineering·Leila SabouriMehdi Moghtadaei

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