Clinical translation of myocardial conditioning

American Journal of Physiology. Heart and Circulatory Physiology
Hans Erik BøtkerNichlas Riise Jespersen

Abstract

Rapid admission and acute interventional treatment combined with modern antithrombotic pharmacologic therapy have improved outcomes in patients with ST elevation myocardial infarction. The next major target to further advance outcomes needs to address ischemia-reperfusion injury, which may contribute significantly to the final infarct size and hence mortality and postinfarction heart failure. Mechanical conditioning strategies including local and remote ischemic pre-, per-, and postconditioning have demonstrated consistent cardioprotective capacities in experimental models of acute ischemia-reperfusion injury. Their translation to the clinical scenario has been challenging. At present, the most promising mechanical protection strategy of the heart seems to be remote ischemic conditioning, which increases myocardial salvage beyond acute reperfusion therapy. An additional aspect that has gained recent focus is the potential of extended conditioning strategies to improve physical rehabilitation not only after an acute ischemia-reperfusion event such as acute myocardial infarction and cardiac surgery but also in patients with heart failure. Experimental and preliminary clinical evidence suggests that remote ischemic conditioning ma...Continue Reading

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Citations

Aug 21, 2019·British Journal of Pharmacology·Petra KleinbongardGerd Heusch
Mar 4, 2020·International Journal of Molecular Sciences·Muntasir BillahRavinay Bhindi
Jul 18, 2019·Journal of Inflammation·Rosangela Nascimento PimentelFrancisco Garcia Soriano
Jul 1, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Hans Erik Bøtker
Aug 19, 2018·Basic Research in Cardiology·Hans Erik BøtkerGerd Heusch
Sep 29, 2019·International Journal of Molecular Sciences·Andrea BaehrChristian Kupatt
Sep 27, 2020·International Journal of Molecular Sciences·Kamilla GömöriPéter Bencsik
Nov 18, 2020·Emerging Topics in Life Sciences·Marvin A Sackner, Jose A Adams
Feb 26, 2021·Scientific Reports·Esben Søvsø Szocska HansenWon Yong Kim
Mar 11, 2021·Basic Research in Cardiology·Thomas Ravn LassenHans Erik Bøtker
Aug 18, 2021·Cardiovascular Drugs and Therapy·Yochai BirnbaumYumei Ye

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Methods Mentioned

BETA
coronary artery bypass

Clinical Trials Mentioned

NCT01857414
NCT02342522
NCT01664611
NCT01817114
NCT03380663

Software Mentioned

BFRE

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