Clinical trial: a dose-response study of fospropofol disodium for moderate sedation during colonoscopy

Alimentary Pharmacology & Therapeutics
L B Cohen

Abstract

An effective agent is needed that provides rapid onset of sedation and quick recovery for patients undergoing colonoscopy. To assess the efficacy and safety of fospropofol disodium in providing sedation in patients undergoing colonoscopy. A randomized, double-blind, multicentre trial evaluated 127 adult patients who received fospropofol (2, 5, 6.5 or 8 mg/kg) or midazolam 0.02 mg/kg following pre-treatment with fentanyl. Supplemental doses of study medication were allowed to reach a Modified Observer's Assessment of Alertness/Sedation scale score < or =4. Efficacy end points included sedation success, measures of clinical benefit, sedation, and recovery as well as patient- and doctor-rated satisfaction. Fospropofol produced a significant dose-dependent increase in sedation success from 24% (2 mg/kg), 35% (5 mg/kg) and 69% (6.5 mg/kg) to 96% (8 mg/kg; P < 0.001). There were also dose-dependent trends for time to sedation, requirements for alternative sedative medication, supplemental doses of sedative and fentanyl, time to ready for discharge and doctor-rated satisfaction scores. Fospropofol was well tolerated, with most adverse events mild-to-moderate in severity. The 6.5 mg/kg dose of fospropofol provides the ideal balance of ...Continue Reading

References

Oct 1, 1978·Anesthesiology·W D OwensE L Spitznagel
Sep 12, 1986·Deutsche medizinische Wochenschrift·H RascheP Schönhöfer
Apr 2, 1998·Neurological Research·M S Luer
May 27, 1999·PharmacoEconomics·S M HollidayG L Plosker
Mar 22, 2000·The Clinical Neuropsychologist·A M ShapiroJ Brandt
Aug 29, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gino PerronPhilippe Béchard
Nov 5, 2003·Gastrointestinal Endoscopy·Lawrence B CohenKenneth M Miller
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian J UlmerDouglas K Rex
May 4, 2004·The British Journal of Oral & Maxillofacial Surgery·Zuhal Küçükyavuz, Mine Cambazoğlu
Jan 6, 2006·The American Journal of Gastroenterology·Sandeep PatelGregory Zuccaro
May 5, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian W SipeBetty Wright

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Citations

Jul 29, 2008·Current Opinion in Anaesthesiology·Frederique S Servin
Jun 11, 2009·Current Opinion in Anaesthesiology·Martin LuginbühlFrank Stüber
Mar 9, 2012·Advances in Urology·Peter T Dorsher, Peter M McIntosh
May 16, 2012·Anesthesia and Analgesia·Amol PatwardhanGregory Dussor
Jan 9, 2010·Therapeutics and Clinical Risk Management·Eric A HarrisKeith A Candiotti
Mar 9, 2010·Drugs·Karly P Garnock-Jones, Lesley J Scott
May 27, 2010·World Journal of Gastroenterology : WJG·Lorella Fanti, Pier-Alberto Testoni
Feb 6, 2013·World Journal of Gastroenterology : WJG·John K TriantafillidisApostolos E Papalois
Sep 8, 2011·Journal of Anaesthesiology, Clinical Pharmacology·Glen Atlas
Nov 7, 2012·Journal of Pharmacology & Pharmacotherapeutics·Bharti MahajanRajesh Mahajan
May 22, 2010·International Journal of Pediatrics·Eric A Harris
Sep 18, 2009·Expert Opinion on Investigational Drugs·Jörg FechnerJürgen Schüttler
Jan 13, 2009·Chest·Michael A Jantz
Jul 4, 2012·Revista española de anestesiología y reanimación·S TelletxeaL F Ortega
Jun 5, 2010·Journal of Clinical Anesthesia·Tong J GanRobert Hardi
May 22, 2010·Anesthesiology Clinics·Peter M Hession, Girish P Joshi
Mar 3, 2010·Critical Care Nursing Clinics of North America·Dixie L Taylor
Apr 14, 2009·Anesthesiology Clinics·Daniel T Goulson, Regina Y Fragneto
Nov 6, 2008·Gastrointestinal Endoscopy·David R LichtensteinJohn J Vargo
May 5, 2011·Anesthesiology Research and Practice·Joseph V PergolizziRobert Taylor
Mar 7, 2015·Journal of Materials Science. Materials in Medicine·Alireza Hassani NajafabadiSina Farzaneh
Oct 15, 2009·The Annals of Pharmacotherapy·Gina D MooreRobert MacLaren
Mar 20, 2009·Current Opinion in Anaesthesiology·Alan Frederick Ross, J Scott Ferguson
Dec 10, 2009·Journal of Clinical Gastroenterology·Lawrence B CohenJacqueline M Kline
Mar 26, 2015·International Anesthesiology Clinics·Romina G Ilic
Dec 19, 2015·Anesthesia and Analgesia·Mark R WilliamsRobert H Dworkin
Mar 22, 2014·Anesthesia and Analgesia·Bing-Chen LangWen-Sheng Zhang
Aug 4, 2010·Expert Review of Gastroenterology & Hepatology·Brijen Shah, Lawrence B Cohen

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