Clinical Trial Assessing the Efficacy of Gabapentin Plus B Complex (B1/B12) versus Pregabalin for Treating Painful Diabetic Neuropathy

Journal of Diabetes Research
Alberto Mimenza Alvarado, Sara Aguilar Navarro

Abstract

Painful diabetic neuropathy (PDN) is a prevalent and impairing disorder. The objective of this study was to show the efficacy and safety of gabapentin (GBP) plus complex B vitamins: thiamine (B1) and cyanocobalamine (B12) compared to pregabalin in patients with moderate to severe intensity PDN. Multicenter, randomized, blind study. Two hundred and seventy patients were evaluated, 147 with GBP/B1/B12 and 123 with PGB, with a 7/10 pain intensity on the Visual Analog Scale (VAS). Five visits (12 weeks) were scheduled. The GBP/B1 (100 mg)/B12 (20 mg) group started with 300 mg at visit 1 to 3600 mg at visit 5. The PGB group started with 75 mg/d at visit 1 to 600 mg/d at visit 5. Different safety and efficacy scales were applied, as well as adverse event assessment. Both drugs showed reduction of pain intensity, without significant statistical difference (P = 0.900). In the GBP/B1/B12 group, an improvement of at least 30% on VAS correlated to a 900 mg/d dose, compared with PGB 300 mg/d. Likewise, occurrence of vertigo was lower in the GBP/B1-B12 group, with a significant statistical difference, P = 0.014. Our study shows that GPB/B1-B12 combination is as effective as PGB. Nonetheless, pain intensity reduction is achieved with 50% of ...Continue Reading

References

Oct 1, 1985·European Journal of Clinical Investigation·D L Vesely
Nov 9, 1974·Lancet·E C Huskisson
Dec 10, 1998·JAMA : the Journal of the American Medical Association·M BackonjaE Garofalo
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·K C GorsonW M Rand
Mar 15, 2003·Clinical Therapeutics·Miroslav Backonja, Robert L Glanzman
Jan 24, 2004·Journal of Manipulative and Physiological Therapeutics·Hugh Hurst, Jennifer Bolton
Oct 25, 2006·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·György Jermendy
Jun 27, 2007·Diabetes, Obesity & Metabolism·Tamás Várkonyi, Peter Kempler
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Cynthia D AngArtemio A Roxas
Oct 14, 2008·Methods and Findings in Experimental and Clinical Pharmacology·Teresa Mixcoatl-ZecuatlVinicio Granados-Soto
Dec 1, 2001·Journal of Clinical Neuromuscular Disease·L JohannsenS H Sindrup
Feb 4, 2010·Clinical Neuropharmacology·Hsiao-Sui LoBor-Show Tzang
Oct 1, 2013·Lancet Neurology·Ian GilronAnthony H Dickenson

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Citations

Feb 21, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·S V KotovV A Shvedov
Jul 30, 2020·Nutrients·Thomas JulianPanagiotis Zis
Feb 6, 2017·Lower Urinary Tract Symptoms·Michael E ChuaMarcelino L Morales
Sep 9, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E S Filatova, Sh F Erdes
Oct 19, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·L R AkhmadeevaE Z Yakupov
Apr 6, 2021·Expert Opinion on Pharmacotherapy·Kalliopi Pafili, Nikolaos Papanas

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