Clinical trial assessing VSL#3 for the treatment of anterior resection syndrome

ANZ Journal of Surgery
Jacqueline H Stephens, Peter J Hewett

Abstract

Restoration of bowel continuity after a temporary loop ileostomy following rectal resection often produces impaired bowel function. The purpose of this clinical trial was to assess the efficacy of a probiotic, VSL#3 (VSL Pharmaceuticals Inc., Gaithersburg, MD, USA), in improving bowel function following ileostomy closure. Between March 2005 and April 2008, a prospective, double-blind, placebo-controlled randomized trial of a probiotic preparation was conducted across four South Australian hospitals. Sixty-three patients who underwent a loop ileostomy reversal were randomized to receive 4-week treatment of either probiotic therapy (n= 31) or placebo (n= 32). Bowel symptomology was collected through a patient-completed bowel diary and the Gastrointestinal Quality of Life Index (GIQLI). Completion rates of the 4-week therapy regime were similar for both groups: 18 active versus 20 placebos. There was no statistically significant difference in the number of patients who withdrew or had adverse events in the two treatment groups. Reasons for patient withdrawal from the study were similar for both groups. Repeated measures analysis of variance showed no statistically significant difference between the GIQLI scores for the two treatme...Continue Reading

References

Oct 1, 1990·Diseases of the Colon and Rectum·W E Roediger
Jan 5, 1989·The New England Journal of Medicine·J M HarigC M Wood
Jan 1, 1995·Gut·I A FinnieJ M Rhodes
Jan 1, 1996·International Journal of Colorectal Disease·H Ortiz, P Armendariz
Jan 1, 1996·International Journal of Colorectal Disease·G N RaoG S Duthie
Jan 6, 1999·The British Journal of Surgery·M SailerA Thiede
Nov 5, 1999·The Journal of Pediatrics·J A VanderhoofR J Young
Jan 14, 2000·The American Journal of Gastroenterology·S L Gorbach
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M D SäemannG J Zlabinger
Nov 1, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G BazzocchiM Campieri
Nov 28, 2002·Digestive Diseases and Sciences·Jeannie S HuangEmily J Davidson
Feb 14, 2003·Lancet·Francisco Guarner, Juan-R Malagelada
Apr 12, 2003·Controlled Clinical Trials·Arthur A StoneMichael R Hufford
Jun 5, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J Camilleri-Brennan, R. J. C Steele
Sep 10, 2003·Biochemical and Biophysical Research Communications·Hitoshi OgawaDavid G Binion
Aug 9, 2005·Gastroenterology Clinics of North America·Paolo GionchettiMassimo Campieri
Mar 8, 2006·World Journal of Gastroenterology : WJG·Irit Chermesh, Rami Eliakim
Sep 15, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R KakodkarS Nundy
Jun 20, 2008·World Journal of Surgery·S D MansfieldS B Kelly
Jan 1, 2009·Nutrition and Cancer·Jan-Michel OtteFrank Schmitz
Dec 19, 2009·Scandinavian Journal of Gastroenterology·Thamara Sigrist LongattiCarlos Augusto Real Martinez

❮ Previous
Next ❯

Citations

Jun 25, 2013·Maturitas·Antonio González-SarríasJuan Carlos Espín
Sep 12, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C L KvasnovskyS Papagrigoriadis
Jun 8, 2012·ANZ Journal of Surgery·David Z Lubowski
Oct 12, 2014·Beneficial Microbes·M Van den NieuwboerE Claasen
Feb 11, 2015·Current Colorectal Cancer Reports·Tina Yen-Ting ChenSøren Laurberg
Jul 28, 2020·Langenbeck's Archives of Surgery·Fabio NoceraDaniel C Steinemann
Jan 10, 2018·International Journal of Colorectal Disease·Audrius DulskasNarimantas E Samalavicius
Apr 10, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T RombeyN S Fearnhead
Nov 29, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Byung Jun YoonSung-Bum Kang
Jan 8, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Peter ChristensenUNKNOWN MANUEL Project Working Group
Dec 16, 2020·Best Practice & Research. Clinical Gastroenterology·David Lam, Oliver Jones
May 1, 2021·Nutrients·Louise PitsillidesChristos Kontovounisios

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.