Clinical trial designs--made to order

Journal of Biopharmaceutical Statistics
J S Andersen

Abstract

At times, clinical trial design presents difficult problems for the consulting statistician. The nature of the disease under study or the inadequacies of standard methodology often suggest alternative strategies for the development of useful clinical trial designs. This paper examines two case of novel clinical trial designs that are "made-to-order" for the problem at hand. Both address disease-specific issues. The first case considers the use of adaptive allocation of treatments to patients in a trial in major depressive disorder. The second case reviews the design of a novel efficacy parameter in advanced pancreatic cancer.

References

Aug 1, 1990·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·S G Arbuck
Dec 1, 1985·Archives of General Psychiatry·A J RushD E Giles
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E S Casper
Apr 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M L RothenbergD D Von Hoff

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Citations

Feb 12, 2002·Statistics in Medicine·Nigel Stallard, William F Rosenberger
Nov 20, 2012·Indian Journal of Human Genetics·Bahareh PourjafariEbrahim Kamrani Saleh
Jun 4, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Karen L CropseyPeter S Hendricks
Dec 20, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·E Melinda Mahabee-GittensJane C Khoury
Apr 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kathrin SchuckMarloes Kleinjan
Dec 13, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Charlotte S ScherphofWilma A M Vollebergh
Jul 3, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Melissa MercincavageKimberly A Horn
Feb 18, 2009·European Journal of Public Health·Lucia M LotreanHein de Vries
Oct 20, 2007·Health Education Research·D PiontekC Donath
Jul 6, 2010·Health Education Research·L M LotreanH De Vries
Sep 16, 2006·Biometrical Journal. Biometrische Zeitschrift·A Lawrence Gould
Aug 28, 2019·Journal of Biopharmaceutical Statistics·Hongjian ZhuLixin Zhang

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