PMID: 6113885Mar 1, 1981Paper

Clinical trial of fazadinium bromide (fazadon)

Canadian Anaesthetists' Society Journal
C E Famewo

Abstract

Fifty healthy Nigerian surgical patients were given fazadinium bromide at a dose level of 10 mg . kg-1 while 30 other similar patients received 1.5 mg . kg-1. Anaesthesia was induced with either thiopentone or alfathesin. Tracheal intubation was satisfactorily accomplished after a mean of 55 seconds with the 1 mg . kg-1 dose and a mean of 32 seconds with the 1.5 mg . kg-1 dose. Duration of action of fazadinium 1 mg . kg-1 was a mean of 42 min (range 30 to 50 min) while the mean for 1.5 mg . kg-1 was 55 min (range 45 to 70 min). There was no significant difference between the thiopentone and alfathesin induction groups. Reversibility with neostigmine was excellent. Whereas the 1 mg . kg-1 dose was satisfactory for normal regular intubation, the 1.5 mg . kg-1 dose is recommended for "crash" intubation. The administration of fazadinium was associated with a stable blood pressure and moderate sinus tachycerdia. No other side effects were seen.

References

Mar 1, 1977·Canadian Anaesthetists' Society Journal·S MehtaK Fidler
Jan 1, 1969·Acta Anaesthesiologica Scandinavica. Supplementum·I Lund, J Stovner
May 1, 1973·Anaesthesia·A J ColemanW P Leary
Sep 1, 1969·Anesthesia and Analgesia·P J SchanerG A Gronert
Jan 9, 1954·British Medical Journal·H C CHURCHILL-DAVIDSON

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Citations

Sep 1, 1981·Canadian Anaesthetists' Society Journal·C E Famewo

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