PMID: 9418187Jan 7, 1998Paper

Clinical trial of immunostimulation with a biological response modifier in unexplained recurrent spontaneous abortion patients

Journal of Clinical Immunology
K KatanoK Aoki

Abstract

We determined clinically whether a killed streptococcal preparation (KSP), a biological response modifier, is as effective as paternal lymphocyte immunotherapy for unexplained recurrent pregnancy abortion (RSA) therapy. The success rate of adverse pregnancy in the study group of 23 RSA cases, who were administered low doses of KSP before and during early pregnancy, was statistically compared with that in a control group of 205 women who received paternal lymphocyte immunotherapy. The association of natural killer (NK) cell activity in the peripheral blood with pregnancy outcome was also assessed. The success rate in the study group was 73.9% (17/23), compared to 75.1% (154/ 205) observed for the controls (not significant). Most of the successful cases exhibited low levels of NK cell activity in the peripheral blood. Immunotherapy with low doses of KSP is as effective as that with paternal lymphocytes, providing a simple and safe alternative therapy for unexplained RSA. Suppression of NK cell activity by some immunoregulatory mechanism was also found to have potential benefit in terms of a successful pregnancy outcome.

Citations

Apr 15, 2008·American Journal of Reproductive Immunology : AJRI·Joanne Kwak-Kim, Alice Gilman-Sachs
Oct 9, 2009·American Journal of Reproductive Immunology : AJRI·Mayumi Sugiura-OgasawaraSadao Suzuki
Oct 31, 2002·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Fatih SendagHuseyin Yilmaz
Nov 22, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·P P SmithT J Clark
Sep 10, 2013·Fertility and Sterility·Kinue KatanoMayumi Sugiura-Ogasawara

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