PMID: 2501077Jan 1, 1989Paper

Clinical trial of norfloxacin in the treatment of uncomplicated gonococcal urethritis: preliminary report

Drugs Under Experimental and Clinical Research
P Cristiano

Abstract

Fifteen male outpatients with uncomplicated gonococcal urethritis were treated by a single oral dose of norfloxacin (800 mg). Fourteen patients completely recovered from infection and a recurrence was noted in only one. Five of the Neisseria gonorrhoeae isolated (33.3%) were penicillin-resistant. However, the extremely low MICs confirm that norfloxacin possesses high antibacterial activity against N. gonorrhoeae. Norfloxacin was well tolerated with only a transient nausea occurring in four patients.

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