PMID: 7034736Dec 1, 1981Paper

Clinical trial of penicillamine in rheumatoid arthritis

Arthritis and Rheumatism
N O RothermichW Bergen

Abstract

The medical records of our first 200 consecutive rheumatoid arthritis patients treated with penicillamine were analyzed retrospectively. All but 5 patients (97.5%) had undergone earlier chrysotherapy that resulted in either therapeutic failure or toxicity. Only 57 patients (28.5%) were still receiving penicillamine on January 1, 1981, and the duration of therapy ranged from 23 to 62 months. The dropout rate due to toxicity, therapeutic failure, relapse, or other reasons was very high (71.5%). Toxic effects required permanent discontinuance in 56 patients (28%). Therapy was discontinued for 36 patients (18%) because of no benefit. A striking number (20) had relapse after therapeutic success and while continuing to take penicillamine, and the therapy had to be discontinued, a relapse rate of 10%. Therapy for the remaining 15.5% was discontinued for miscellaneous reasons that were not related to penicillamine per se: patient anxiety (6%), lost to followup (5%), hospitalization for reasons unrelated to penicillamine therapy (2%), lack of cooperation and study protocol (1% each), or pregnancy (0.5%). By our criteria, 142 patients (71%) received benefit (remission or improvement). Therapy results for these patients were as follows: s...Continue Reading

References

Nov 1, 1976·Arthritis and Rheumatism·N O RothermichM H Thomas
Nov 1, 1974·Annals of the Rheumatic Diseases·E C HuskissonJ A Wojtulewski
Mar 1, 1970·Arthritis and Rheumatism·J ZucknerG E Gantner
Jan 1, 1980·Annals of Internal Medicine·W M O'Brien
Jan 1, 1980·Annals of Internal Medicine·H B SteinH S Robinson

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Citations

Jan 1, 1988·Rheumatology International·D L ScottE C Huskisson
Feb 1, 1984·Annals of the Rheumatic Diseases·T PullarH A Capell
Feb 1, 1984·Annals of the Rheumatic Diseases·D L ScottP A Bacon
Jan 1, 1988·Mayo Clinic Proceedings·S E Gabriel, H S Luthra
Dec 1, 1982·Journal of Clinical and Hospital Pharmacy·D ScottP Bacon
Jan 1, 1986·Scandinavian Journal of Rheumatology·K Ishikawa, M Sakaguchi
Feb 1, 1992·Baillière's Clinical Rheumatology·J J Rasker, J A Cosh
Jan 1, 1984·Scandinavian Journal of Rheumatology·F SpeerstraJ P Vandenbroucke
Dec 1, 1982·Annals of the Rheumatic Diseases·D Raman, I Haslock
Jan 1, 1989·Annals of the Rheumatic Diseases·G M Mody, O L Meyers
Jun 1, 1983·Arthritis and Rheumatism·C L Bell, F M Graziano
Dec 12, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Danushika C ManatungaK M Nalin de Silva
Jul 1, 1985·Medicinal Research Reviews·V J StecherD M Bailey
Jun 1, 1990·Seminars in Arthritis and Rheumatism·M J WijnandsL B van de Putte
May 1, 1986·Seminars in Arthritis and Rheumatism·H E Howard-LockW F Kean

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