PMID: 6989170Jan 1, 1980Paper

Clinical trial of prednimustine, Leo-1031 (NSC-134087), in patients with non-Hodgkin lymphomata and chronic lymphocytic leukaemia previously treated with steroids and alkylating agents

Acta Medica Scandinavica
J Pedersen-BjergaardN I Nissen

Abstract

Prednimustine, a chlorambucil ester of prednisolone, was administered to 16 patients with non-Hodgkin lymphomata (NHL) and 14 patients with chronic lymphocytic leukaemia (CLL), all previously treated with steroids and alkylating agents. Response was obtained in 8 patients with NHL and 11 patients with CLL. Two NHL patients had long-lasting complete remissions. Median duration of response for lymphomata was 12 weeks, for CLL more than 15 weeks. Delayed reversible and rather pronounced myelosuppression was the major side-effect observed in median 6 weeks from the start of Prednimustine with a median duration of 4 weeks.

References

Apr 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L Brandt, I Könyves
Jan 1, 1978·Oncology·R Y KirdaniA A Sandberg
Jan 1, 1978·Oncology·S B LeleG P Murphy
Jan 1, 1978·American Journal of Hematology·R T SilverO Glidewell
Dec 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I KönyvesH Westerberg-Larsson

Citations

Jan 1, 1992·Cancer Chemotherapy and Pharmacology·E MuschE Riedel

Related Concepts

NSC-3088
Clinical Trials
Lymphoid Leukemia
Lymphoma
Stereocyt

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