Clinical trial to assess the effect of physical exercise on endothelial function and insulin resistance in pregnant women.

Trials
Robinson Ramirez-VelezP López-Jaramillo

Abstract

Preeclampsia (PE) is a common maternal disease that complicates 5 to 10% of pregnancies and remains as the major cause of maternal and neonatal mortality. Cost-effective interventions aimed at preventing the development of preeclampsia are urgently needed. However, the pathogenesis of PE is not well known. Multiple mechanisms such as oxidative stress, endothelial dysfunction and insulin resistance may contribute to its development. Regular aerobic exercise recovers endothelial function; improves insulin resistance and decreases oxidative stress. Therefore the purpose of this clinical trial is to determine the effect of regular aerobic exercise on endothelial function, on insulin resistance and on pregnancy outcome. 64 pregnant women will be included in a blind, randomized clinical trial, and parallel assignment. The exercise group will do regular aerobic physical exercise: walking (10 minutes), aerobic exercise (30 minutes), stretching (10 minutes) and relaxation exercise (10 minutes) in three sessions per week. Control group will do the activities of daily living (bathing, dressing, eating, and walking) without counselling from a physical therapist. NCT00741312.

References

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Citations

Jul 31, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Robinson Ramírez-Vélez
Jul 8, 2011·The Journal of Obstetrics and Gynaecology Research·Robinson Ramírez-VélezPatricio López-Jaramillo
Feb 22, 2012·Journal of Physiotherapy·Angelo Fernando Robledo-ColoniaRobinson Ramírez-Vélez
Nov 26, 2010·Journal of Physiotherapy·Ana Victoria Montoya ArizabaletaRobinson Ramirez-Velez
Nov 29, 2017·BMC Pregnancy and Childbirth·Robinson Ramírez-VélezAntonio García-Hermoso
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Shanshan HanCaroline A Crowther
Apr 21, 2006·The Cochrane Database of Systematic Reviews·S Meher, L Duley

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