PMID: 9647954Jul 2, 1998Paper

Clinical trials and human sexuality: basic concepts and problems

International Journal of Impotence Research
John Bancroft

Abstract

In considering the evaluation of pharmacological agents in the treatment of sexual dysfunction, four fundamental issues are discussed in this paper: (1) most pharmacological agents which have been used for this purpose act on neurotransmitter systems which are not specific to sexual response; (2) even when a sexually relevant pharmacological effect can be assumed, its effect on sexual behavior will be modulated by information processing; (3) the first attempts to evaluate the agent should focus on direct effects on the individual receiving the drug; and (4) evaluation of the relevance of the direct pharmacological effect on the well-being of a sexual relationship requires control of the considerable variance which exists in the capacity for change in sexual relationships.

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