Clinical trials for neurodevelopmental disorders: At a therapeutic frontier

Science Translational Medicine
Shafali S Jeste, Daniel H Geschwind

Abstract

A well-powered clinical trial that failed to replicate promising results in animal models of fragile X syndrome yields important lessons for clinical trial design (Berry-Kravis et al., this issue).

References

Jun 29, 2004·Trends in Neurosciences·Mark F BearStephen T Warren
Feb 15, 2011·Neurobiology of Disease·Josien LevengaBen A Oostra
Oct 25, 2011·Annual Review of Pathology·Michael R SantoroStephen T Warren
Nov 13, 2012·Behavioural Brain Research·Ilse GantoisRob Willemsen
Nov 1, 2013·Psychopharmacology·Sébastien JacquemontBaltazar Gomez-Mancilla
Jan 15, 2016·Science Translational Medicine·Elizabeth Berry-KravisFlorian von Raison

❮ Previous
Next ❯

Citations

Mar 22, 2016·Nature Neuroscience·Elizabeth K Ruzzo, Daniel H Geschwind
Apr 7, 2016·Nature Medicine·Luis de la Torre-UbietaDaniel H Geschwind
Dec 19, 2018·Brain Sciences·Craig A EricksonElizabeth Berry-Kravis
Mar 2, 2018·Current Opinion in Neurology·Rujuta B WilsonNicole J Rinehart
Oct 28, 2016·Nature Neuroscience·Michael J GandalDaniel H Geschwind
Oct 28, 2016·Nature Neuroscience·Yehezkel Sztainberg, Huda Y Zoghbi
May 16, 2017·Journal of Neurodevelopmental Disorders·Michael S SidorovBenjamin D Philpot
Jun 16, 2017·Journal of Neurodevelopmental Disorders·Dejan B BudimirovicWalter E Kaufmann
May 26, 2018·Molecular Neurobiology·Thomas C Dockendorff, Mariano Labrador
Jun 16, 2017·Journal of Neurodevelopmental Disorders·Craig A EricksonElizabeth Berry-Kravis
Apr 28, 2019·Autism : the International Journal of Research and Practice·Antonio Y HardanStephen M Graham
Dec 14, 2018·Journal of Neurodevelopmental Disorders·Rujuta B WilsonShafali S Jeste
Nov 20, 2020·American Journal on Intellectual and Developmental Disabilities·Melissa RaspaJeffrey L Neul
Nov 14, 2019·Cell Reports·Rui Tiago PeixotoBernardo Luis Sabatini
Dec 10, 2017·Current Opinion in Neurobiology·Carla Em GoldenSilvia De Rubeis
Mar 31, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C M Díaz-CanejaC Arango
May 4, 2021·Journal of Autism and Developmental Disorders·Corneliu BolboceanJ Lloyd Holder
May 28, 2021·Scientific Reports·Alexandra C SalemEric Fombonne
Jun 11, 2021·Journal of Developmental and Behavioral Pediatrics : JDBP·Kirsten M ChristensenNicole T Baumer
Jun 24, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·James T McCrackenUNKNOWN ISCTM/ECNP ASD Working Group
Sep 10, 2021·Molecular Psychiatry·Simone ChiolaAleksandr Shcheglovitov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Advances in Child Development and Behavior
Kim M CornishNicole J Rinehart
Results and Problems in Cell Differentiation
R F KooyP J Willems
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
Tadao Arinami
© 2022 Meta ULC. All rights reserved