Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming Barriers.

JCO Global Oncology
Lilie L LinSatish Gopal

Abstract

The aim of this study was to review the current status of clinical trials for HIV-associated malignancies in people living with HIV in sub-Saharan Africa (SSA) and efforts made by the AIDS Malignancy Consortium (AMC) to build capacity in SSA for HIV malignancy research. All malignancy-related clinical trials in 49 SSA countries on ClinicalTrials.gov were reviewed and evaluated for inclusion and exclusion criteria pertaining to HIV status. Additional studies by AMC in SSA were compiled from Web-based resources, and narrative summaries were prepared to highlight AMC capacity building and training initiatives. Of 96 cancer trials identified in SSA, only 11 focused specifically on people living with HIV, including studies in Kaposi sarcoma, cervical dysplasia and cancer, non-Hodgkin lymphoma, and ocular surface squamous neoplasia. Recognizing the increasing cancer burden in the region, AMC expanded its clinical trial activities to SSA in 2010, with 4 trials completed to date and 6 others in progress or development, and has made ongoing investments in developing research infrastructure in the region. As the HIV-associated malignancy burden in SSA evolves, research into this domain has been limited. AMC, the only global HIV malignanc...Continue Reading

References

May 1, 1995·Survey of Ophthalmology·G A Lee, L W Hirst
Jan 1, 1996·Clinical Oncology : a Journal of the Royal College of Radiologists·M HarrisonD Tomlinson
Dec 13, 1997·Australian and New Zealand Journal of Ophthalmology·G A Lee, L W Hirst
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keith DredgeAngus G Dalgleish
Jan 11, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Z M ChirenjeM Mlingo
Jul 19, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephen F MorinT Anne Richards
Sep 26, 2003·Cornea·Surendra Basti, Marian S Macsai
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Walter O MwandaScot C Remick
Mar 16, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·E A AbayomiL W Ayers
Jul 11, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John F DeekenBruce J Dezube
Apr 9, 2013·The Lancet Oncology·Adekunle AdesinaTimothy R Rebbeck
Apr 9, 2013·The Lancet Oncology·May Abdel-WahabEduardo Rosenblatt
Apr 16, 2013·PLoS Medicine·Leigh F JohnsonUNKNOWN International Epidemiologic Databases to Evaluate AIDS Southern Africa Collaboration
Apr 25, 2013·The British Journal of Ophthalmology·T TiongB Dhillon
Oct 25, 2013·Lancet·Steven G DeeksDiane V Havlir
Nov 15, 2013·The New England Journal of Medicine·Kieron DunleavyWyndham H Wilson
Apr 12, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erna Milunka KojicSusan Cu-Uvin
Apr 23, 2014·International Journal of Radiation Oncology, Biology, Physics·Niloy R DattaStephan Bodis
Aug 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Clement A AdebamowoSusan E Krown
Sep 25, 2014·MBio·Mina C HosseinipourDirk P Dittmer
Apr 7, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Innocent MutyabaCorey Casper
Jun 17, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anna E CoghillEric A Engels
Jun 18, 2015·PloS One·Marie-Anne VandenhendeUNKNOWN ANRS EN20 Mortalité 2010 study group
Aug 8, 2015·The Lancet Oncology·Sara StulacPaul E Farmer
Aug 13, 2015·PloS One·Scott Dryden-PetersonShahin Lockman
Nov 19, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ann M NelsonYawale Iliyasu
Sep 8, 2016·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·Johann Wilhelm SchneiderSylvia Silver
Sep 9, 2016·Current Opinion in HIV and AIDS·Lameck ChinulaSatish Gopal
Nov 20, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark N PolizzottoRobert Yarchoan
Jun 18, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anna E CoghillEric A Engels
Jan 25, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mina C HosseinipourUNKNOWN A5264/AMC-067 REACT-KS Team
Mar 15, 2018·The New England Journal of Medicine·Robert Yarchoan, Thomas S Uldrick

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Citations

Dec 19, 2020·Current Opinion in Infectious Diseases·Mazvita MuchengetiTafadzwa G Dhokotera
Feb 24, 2021·AIDS·Kathryn Lurain, Sam M Mbulaiteye
Aug 7, 2021·JAMA : the Journal of the American Medical Association·Satish Gopal, Norman E Sharpless

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Methods Mentioned

BETA
biopsy
biopsies

Clinical Trials Mentioned

NCT01352117
NCT01435018
NCT03077451
NCT03601806
NCT03324009
NCT03931083
NCT04092257
NCT04191967
NCT03284866
NCT01590017

Software Mentioned

MobileODT
GeneXpert

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