Clinical trials in spinal cord injury

Journal of Neurotrauma
Andrew R Blight, Mark H Tuszynski

Abstract

Progress in promoting axonal plasticity and regeneration in animal models of spinal cord injury (SCI) has led to novel prospects for the initiation of human clinical trials in the near future. This review discusses a number of considerations in the path to translating a preclinical candidate from the laboratory to clinical testing. We will also briefly discuss issues associated with the design, performance, analysis, and reporting of human clinical trials in SCI. It is important, for both the medical community and the spinal cord injured community, that objective scientific and medical standards are adopted in the clinical translation of potentially promising, but as yet unproven, therapies for SCI.

References

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Citations

Dec 31, 2011·Translational Stroke Research·Adam R FergusonJessica L Nielson
Mar 20, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yvette S NoutMark H Tuszynski
Dec 9, 2009·Expert Reviews in Molecular Medicine·Fardad T AfshariJames W Fawcett
Jul 22, 2006·Nature Reviews. Neuroscience·Sandrine ThuretFred H Gage
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Paola NixMichael Bastiani
Jan 8, 2009·Journal of Neurotrauma·Cassie S Mitchell, Robert H Lee
Mar 9, 2011·Journal of Neurotrauma·Michael G FehlingsLisa McKerracher
Mar 1, 2012·Journal of Neurotrauma·Marco D SoraniJacqueline C Bresnahan
Aug 23, 2007·ILAR Journal·Stephen M OniferStephen W Scheff
Jan 29, 2008·British Journal of Neurosurgery·S Knafo, D Choi
Nov 15, 2011·Pathology, Research and Practice·Bruno TorresEliane Melo
Nov 17, 2010·Neuroscience Research·María José G M PiedrasCarmen Cavada
Oct 16, 2007·Experimental Neurology·Nicole J Tester, Dena R Howland
Jun 4, 2011·Neurorehabilitation and Neural Repair·Hubertus J A van HedelUNKNOWN EM-SCI Study Group
Jan 25, 2017·Spinal Cord·M Sharif-AlhoseiniV Rahimi-Movaghar
Nov 20, 2015·Journal of Neurophysiology·Rui YanRiyi Shi

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