PMID: 8949756Jan 1, 1996Paper

Clinical trials of neutron radiotherapy in the United States

Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
K L LindsleyT W Griffin

Abstract

The development of clinical neutron facilities in the 1980s, capable of delivering high energy neutrons spurred full scale phase III testing of neutron beam radiotherapy in a number of tumors including salivary gland, head and neck, prostate, and non small-cell lung cancer. The Radiation Therapy Oncology Group (RTOG) and the Medical Research Council (MRC) jointly sponsored a randomized trial for the treatment of advanced stage salivary gland tumors comparing neutron to conventional photon and/or electron radiotherapy. Although no improvement in survival was seen, the study demonstrated a striking and statistically significant difference in the local-regional control of unresectable salivary gland tumors (56 vs 17%), favoring neutron beam irradiation. Subsequent clinical trials of neutron beam irradiation were initiated by the Neutron Therapy Collaborative Working Group (NTCWG) sponsored by the National Cancer Institute (NCI). A phase III trial comparing neutron to photon radiotherapy for inoperable regional non-small cell lung cancer showed no overall improvement in survival. However, a statistically significant improvement in survival was observed in the subset of patients with squamous cell histology. The NTCWG trial comparin...Continue Reading

References

Nov 1, 1988·International Journal of Radiation Oncology, Biology, Physics·T W GriffinM H Maor
Feb 1, 1986·American Journal of Clinical Oncology·M H MaorT F Pajak
Feb 1, 1987·International Journal of Radiation Oncology, Biology, Physics·W DuncanJ R Williams
Sep 1, 1987·International Journal of Radiation Oncology, Biology, Physics·M Catterall, R D Errington
Dec 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J J Battermann, B J Mijnheer
Dec 1, 1984·International Journal of Radiation Oncology, Biology, Physics·T W GriffinG E Laramore
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W DuncanG R Kerr
Sep 1, 1982·International Journal of Radiation Oncology, Biology, Physics·H J Eichhorn
May 1, 1981·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J J BattermannH A van Peperzeel
Dec 1, 1994·International Journal of Radiation Oncology, Biology, Physics·M Austin-SeymourT Griffin
Jul 1, 1993·Archives of Otolaryngology--head & Neck Surgery·T A BuchholzT W Griffin

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Citations

Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Rolf F BarthEinar K Rofstad
Feb 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Herman SuitAlexei Trofimov
Feb 8, 2002·Medical Physics·Haijun SongRobert E Klinkowstein
Apr 12, 2018·Physics in Medicine and Biology·Gregory B MoffittGeorge E Laramore
Jun 29, 2000·Medical Oncology·S N PentyalaS A Khan
Sep 18, 2021·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Giulio Cantù

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