Clinical trials of stereotactic ablative radiotherapy for prostate cancer: updates and future direction

Future Oncology
H Bindu Musunuru, Andrew Loblaw

Abstract

Stereotactic body radiotherapy, also known as stereotactic ablative body radiotherapy (SABR), is an emerging treatment option for lung, prostate, liver and other tumors. Key factors in SABR are delivery of a high-dose radiation per fraction, proper patient positioning and target localization. Our review details the various radiotherapy techniques, dose fractionation schedules and toxicities for prostate SABR. Ongoing Phase II/III SABR studies across various risk groups have been included. It also discusses the role of conscientious focal dose escalation of the dominant intraprostatic nodule, integrating multiparametric MRI into radiotherapy protocols and finally cost-effectiveness of SABR.

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Citations

Jan 23, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H Bindu MusunuruAndrew Loblaw
Mar 31, 2016·International Journal of Radiation Oncology, Biology, Physics·Hima Bindu MusunuruAndrew Loblaw
May 6, 2015·International Journal of Radiation Oncology, Biology, Physics·Glenn BaumanGeorge Rodrigues
Jul 6, 2016·Frontiers in Oncology·James CoatesIssam El Naqa
Jul 18, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Carl SalembierDirk Van Gestel

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Clinical Trials Mentioned

NCT01423474
NCT01764646
NCT01505075
NCT01953055
NCT02031328
NCT01409473
NCT01856855
NCT02145494
NCT01976962
NCT01839994

Software Mentioned

ViewRay
PATRIOT
SATURN

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