Clinical trials of topical interferon therapy of ulcerative viral keratitis

The Journal of Infectious Diseases
B R JonesK Cantell

Abstract

An open trial suggested that monkey interferon had a therapeutic effect on ulcerative vaccinial keratitis in humans. A randomized, double-blind, placebo-controlled trial of either monkey interferon or drops of idoxuridine (given hourly by day and at 2-hr intervals by night for three days) suggested a therapeutic effect from idoxuridine but not from monkey interferon. Results of experiments with rabbits suggested that a daily application of human interferon (1.1 X 10(7) international units/ml) would be effective in the prevention of herpetic ulcers but might not affect established lesions. Preliminary results are encouraging in a placebo-controlled, randomized trial of human interferon given once daily for seven days for prevention of recrudescence of epithelial herpetic lesions after minimal wiping debridement with a cotton-tipped swab. The design of the trial is closely analogous to that of the experiments with rabbits and permits ethically acceptable, placebo-controlled trials of antiviral agents.

Citations

Nov 18, 1976·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·R SundmacherK Cantell
Jan 1, 1980·Pharmacology & Therapeutics·W M Shannon, F M Schabel
Oct 1, 1983·Japanese Journal of Medical Science & Biology·S Yamazaki
Mar 1, 1981·American Journal of Ophthalmology·Kirk R WilhelmusB R Jones
Sep 18, 1977·Blut·H Strander
Nov 1, 1980·Indian Journal of Pediatrics·S Bogger-Goren, P L Ogra
Jan 1, 1994·Biotherapy·N B Finter
Aug 1, 1984·European Journal of Clinical Microbiology·P G Higgins
Jul 17, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·R SundmacherD Neumann-Haefelin
Nov 30, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·R SundmacherD Neumann-Haefelin
Jul 31, 2007·The Ocular Surface·Scott GuessJames Chodosh
Jun 1, 1986·International Journal of Dermatology·Q S Ringenberg, P C Anderson
Oct 1, 1982·Medicinal Research Reviews·Z E Dziewanowska, S Pestka
Apr 17, 2015·The Cochrane Database of Systematic Reviews·Kirk R Wilhelmus
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G M Scott
Mar 1, 1986·International Journal of Dermatology·T F Scott

Related Concepts

Administration, Topical
Metazoa
Anthropoidea
Clinical Trials
Corneal Ulcer
Debridement
Drug Evaluation
Idoxuridine, Radical Ion (1-)
Interferons
Keratitis, Dendritic

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.