Clinical trials: study design and analysis

European Journal of Radiology
Y van der Graaf

Abstract

To enable doctors to select the best therapeutic strategy, the value of the various options needs to be determined. The best approach to the evaluation of therapeutic effectiveness and side effects is a randomised clinical trial. Traditionally, such trials have been mainly conducted to evaluate new drugs. However, other medical interventions, such as surgical and radiological procedures and lifestyle changes, also require methodologically sound evaluation. In this article, some of the basic principles of the study design of randomised clinical trials will be discussed, such as study group comparability, treatment, data collection and statistical analysis, as well as issues relating to randomisation, outcome and blinding. Attention is also paid to some of the ethical aspects.

References

Nov 17, 1977·The New England Journal of Medicine·T C ChalmersA M Kunzler
Jul 20, 1989·The New England Journal of Medicine·UNKNOWN Steering Committee of the Physicians' Health Study Research Group

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Citations

Sep 27, 2000·The Journal of Prosthetic Dentistry·S Kiat-amnuayL J Goldsmith
Dec 23, 2004·Archives of Disease in Childhood·B K van StaaijA W Hoes
Dec 1, 2006·Statistics in Medicine·M J CampbellN Klar
Dec 26, 2006·Journal of Community Health·Regina Otero-SabogalFarzaneh Tabnak
Jan 26, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Halil SağlamOmer Tarim
May 9, 2007·Statistical Methods in Medical Research·Mary L YoungMark Wolfson
Mar 17, 2019·American Journal of Epidemiology·Susan M ShortreedJennifer C Nelson
Dec 20, 2007·International Review of Psychiatry·C Hendricks BrownRobert D Gibbons
Dec 8, 2007·Public Health Nutrition·Teri L Burgess-ChampouxMarla Reicks
May 1, 2008·Suicide & Life-threatening Behavior·Anat Brunstein KlomekMadelyn S Gould
Jul 26, 2008·Annual Review of Psychology·John W Graham
Jul 12, 2008·Annual Review of Psychology·William R Shadish, Thomas D Cook
Oct 24, 2018·Behavior Research Methods·Mirjam Moerbeek
May 5, 2000·The Journal of Behavioral Health Services & Research·R K HerschJ V Trudeau
Mar 20, 2009·Annual Review of Public Health·C Hendricks BrownRobert D Gibbons
May 15, 2009·Prevention Science : the Official Journal of the Society for Prevention Research·Knowlton W JohnsonBrian Saylor
Jun 19, 2009·PLoS Medicine·Bruno Giraudeau, Philippe Ravaud
Aug 24, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J R Curtis
Mar 29, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K S LeungW H Cheung
Oct 29, 2009·Journal of General Internal Medicine·Charles D MacleanBenjamin Littenberg
May 14, 2005·Prevention Science : the Official Journal of the Society for Prevention Research·Keith SmolkowskiJason Blair
Sep 18, 2010·Clinical Orthopaedics and Related Research·Patricia H RosenbergerJeannette R Ickovics
Jul 14, 2011·Statistics in Medicine·Matthew J GurkaKeith E Muller
Jan 18, 2012·Prevention Science : the Official Journal of the Society for Prevention Research·Sam VuchinichLeonard Bickman
Feb 3, 2012·Journal of General Internal Medicine·Eleanor Bimla SchwarzGary S Fischer
Feb 9, 2012·Prevention Science : the Official Journal of the Society for Prevention Research·Elizabeth J D'AmicoHarold D Green
Mar 3, 2012·BMC Public Health·Teresa Shamah LevyIgnacio Méndez Gómez Humarán
Jun 6, 2019·Stroke; a Journal of Cerebral Circulation·Elena OlmastroniAlberico Luigi Catapano

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