Clinical trials with multiple endpoints can establish a correlation, but not (yet) causality, between dietary supplementation with omega-3 fatty acids and keratoconjunctivitis sicca

Journal of Medical Economics
Roger Lee Mendoza

Abstract

We review clinical evidence of therapeutic efficacy and effectiveness of omega-3 fatty acids (omega-3s) in keratoconjunctivitis sicca, colloquially known as dry eye disease. In doing so, we identify relevant literature to address the following questions: (1) What definitive guidance can clinical evidence offer eye physicians and their patients? (2) What aspects of omega-3 supplementation lack definitive evidence, and how might economic assessments help? A targeted and systematic search strategy based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) was designed in this study for refereed clinical trials of omega-3s in dry eye treatment. Four key databases were accessed. Records were filtered through a three-step process using predetermined inclusion criteria. Data was extracted for experimental design, sample population characteristics, content of test and control groups, symptoms and associated opthalmologic conditions, diagnostic measures, patient health outcomes, adverse events, and model time horizon. A total of 219 records were initially identified, of which 21 prospective clinical trials, with a total of 2,973 participants, were admitted for review. Clinical evidence indicates that daily oral...Continue Reading

References

Jan 22, 2003·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Milton C WeinsteinUNKNOWN ISPOR Task Force on Good Research Practices--Modeling Studies
May 4, 2004·Journal of Biomedical Informatics·Paul R Falzer
Oct 8, 2005·The American Journal of Clinical Nutrition·Biljana MiljanovićDebra A Schaumberg
Feb 14, 2006·Current Pharmaceutical Biotechnology·C S RamaaV J Kadam
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Apr 1, 2011·Investigative Ophthalmology & Visual Science·Kelly K NicholsDavid A Sullivan
May 21, 2011·Current Opinion in Ophthalmology·Allison L Rand, Penny A Asbell
May 7, 2013·Ophthalmology·Haleh KangariMehdi Khabazkhoob
Sep 17, 2013·Clinical Interventions in Aging·Andrea OleñikIgnacio Mahillo-Fernández
Sep 7, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Aihua Liu, Jian Ji
Feb 24, 2015·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Rahul BhargavaManjushri Kumar
Feb 27, 2015·Cornea·Rahul Bhargava, Prachi Kumar
Apr 7, 2016·Current Eye Research·Rahul BhargavaShalini Sharma
Jul 22, 2016·Cornea·Alice T EpitropoulosHenry D Perry
Nov 1, 2016·Journal of the American College of Nutrition·Constantine D GeorgakopoulosCaterina Psachoulia
Mar 16, 2017·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Holly R ChinneryLaura E Downie
Jan 31, 2018·Journal of Medical Economics·Roger Lee Mendoza

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