Clinical types of corneal transplant rejection. Their manifestations, frequency, preoperative correlates, and treatment

Archives of Ophthalmology
O C Alldredge, J H Krachmer

Abstract

We report a retrospective series of 156 penetrating keratoplasties that were performed in 144 patients during a two-year period, with a minimum of one-year follow-up. Three different types of rejection were identified--endothelial rejection, epithelial rejection, and subepithelial infiltrates (SEIs). We also report the clinical signs, frequency, preoperative correlates, significance, and treatment of each type of rejection. The overall frequency of any kind of rejection was 29%. Endothelial rejection was seen in 21% of the grafts, epithelial rejection was seen in 10% of the grafts, and SEIs was seen in 15% of the grafts. The frequency of endothelial rejection increased with preoperative corneal vascularization. All three types of rejection decreased in frequency with the increasing age of the recipient. Endothelial rejection was more successfully treated in the cases that had no preoperative stromal vascularization.

Citations

May 27, 1997·Transplantation·M R DanaJ W Streilein
Apr 4, 2000·Cornea·M K AasuriS Gupta
Nov 30, 2000·Clinical & Experimental Ophthalmology·N H BarkerK A Williams
Jul 31, 2003·Current Opinion in Ophthalmology·David J CarlssonMay Griffith
Apr 7, 2007·Journal of Medical Case Reports·Motoko KawashimaMasakazu Yamada
Jul 22, 2008·Veterinary Ophthalmology·Wendy M TownsendSheryl G Krohne
Aug 12, 2009·Acta Ophthalmologica·Uwe Pleyer, Stephan Schlickeiser
Aug 21, 2013·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Silvana MadiMassimo Busin
Jul 1, 2011·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Larry FerdinandRobert A Copeland
May 2, 2014·The British Journal of Ophthalmology·Lana A FarajHarminder S Dua
Nov 13, 2015·Scientific Reports·Zhaochuan LiuWeirong Chen
Nov 11, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jacek P SzaflikJerzy Szaflik
Dec 23, 2015·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Nicole Carnt, Fiona Stapleton
Oct 27, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Luca BuzzonettiGiancarlo Iarossi
Apr 5, 2017·Japanese Journal of Ophthalmology·Antonio Di ZazzoMichele Fortunato
Jun 20, 2017·Case Reports in Ophthalmology·Sunali Goyal, Sami H Uwaydat
Nov 1, 1992·The British Journal of Ophthalmology·G K ChauC K Rostron
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·E HåskjoldR Bjerknes
May 25, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas ReinhardRainer Sundmacher
Dec 11, 2007·Stem Cells·Francisco Arnalich-MontielMaria P De Miguel
Jan 7, 2009·International Ophthalmology Clinics·Helene Lam, M Reza Dana
Nov 13, 2009·Cornea·Vincenzo Sarnicola, Patricia Toro
May 9, 2008·Eye & Contact Lens·Zeynep OzbekChristopher J Rapuano
Mar 11, 2011·Cornea·Deepak Gupta, Chris Illingworth
Mar 1, 1995·The British Journal of Ophthalmology·K TsubotaN Sato
Jan 1, 1988·Eye·R J Morris, C M Kirkness
Aug 1, 1994·The British Journal of Ophthalmology·D F Larkin
Jul 3, 1986·The New England Journal of Medicine·R L Lindstrom
Jan 1, 1989·Acta Ophthalmologica. Supplement·R A Thoft
Dec 1, 1996·Acta Ophthalmologica Scandinavica·S YamagamiT Tsuru
Mar 13, 2003·Immunology and Cell Biology·Michael A ThielKeryn A Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.