Clinical updates in adult acute lymphoblastic leukemia

Critical Reviews in Oncology/hematology
Omar Al UstwaniMeir Wetzler

Abstract

Acute lymphoblastic leukemia (ALL) is a clonal disease characterized by B or T lineage. Here we cover the clinical manifestations, pathophysiology and therapy for ALL. Additionally, we will discuss the evidence for minimal residual disease assessment, novel molecular targets and newly developed targeted therapies. The separation of ALL into Philadelphia chromosome positive and recently into Philadelphia-like disease represents the most exciting developments in this disease. Finally, the advent of new immunotherapeutic approaches led us to predict that in few years, ALL therapy might be based heavily on non-chemotherapeutic approaches.

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Citations

Mar 30, 2016·International Immunology·Matthew J Frigault, Marcela V Maus
Jan 14, 2018·Zeitschrift für Rheumatologie·M SchmalzingJ Atta
Feb 18, 2020·Molecular and Clinical Oncology·Konstantinos TsamakisEmmanouil Rizos
Feb 2, 2019·British Journal of Haematology·Guoqiao ZhengKari Hemminki
Apr 20, 2018·Journal of Cellular and Molecular Medicine·Desheng KongYinghua Li
Jul 14, 2020·Nutrition and Cancer·Hossein Khadem HaghighianMaria Kavianpour
Dec 27, 2016·Frontiers in Pharmacology·Stefania TrinoPellegrino Musto
Jun 13, 2017·Leukemia & Lymphoma·Ankit KansagraMark Litzow
Jul 6, 2021·Geriatric Orthopaedic Surgery & Rehabilitation·Cheng Liu, Cuili Shu
Oct 16, 2021·Cancer Science·Morito KurataTakuro Nakamura

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