PMID: 6166192Jun 1, 1981Paper

Clinical use of beta-thromboglobulin levels in diagnosing and treating consumptive and immune thrombocytopenia

American Journal of Hematology
M D Rubenstein, R T Wall

Abstract

Plasma beta-thromboglobulin (beta-TG), a platelet-specific protein, is a marker of intravascular platelet degranulation. We measured plasma beta-thromboglobulin by radioimmunoassay in 13 patients with thrombocytopenia of various etiologies to determine whether or not the test is clinically useful in the differential diagnosis of thrombocytopenia. Four patients with intravascular platelet consumption (three with thrombotic thrombocytopenic purpura and one with vasculitis) had significantly higher plasma beta-thromboglobulin levels than four patients with extravascular platelet destruction due to idiopathic thrombocytopenic purpura. Five patients with thrombocytopenia and decreased numbers of megakaryocytes in the bone marrow also had beta-thromboglobulin levels that were not elevated. Two patients with thrombotic thrombocytopenic purpura achieved clinical remission associated with a decrease in beta-TG level to the normal range. Plasma beta-thromboglobulin determination can be useful in determining the mechanism of thrombocytopenia when bone marrow examination demonstrates adequate megakaryocyte numbers.

References

Sep 1, 1979·British Journal of Haematology·G CellaV V Kakkar
Nov 16, 1972·The New England Journal of Medicine·L A Harker, S J Slichter
Jan 1, 1980·Thrombosis Research·D DeppermannD Post

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Citations

Jul 1, 1993·British Journal of Haematology·R C TaitJ F Davidson
May 1, 1994·British Journal of Haematology·R C TaitR W Carrell
Dec 1, 1994·The Australian and New Zealand Journal of Surgery·M D KellyG J Leslie
May 1, 2008·Paediatric Anaesthesia·Philip C Jackson, Judith M Morgan
Jan 1, 1982·Critical Reviews in Clinical Laboratory Sciences·A C de BoerA G Turpie
Nov 9, 2002·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroBaha Sibai

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