Clinical use of colony-stimulating factor-1 in ovulation induction for poor responders

Fertility and Sterility
Akihisa TakasakiHitoshi Okamura

Abstract

To evaluate the benefit of colony-stimulating factor-1 (CSF-1) adjuvant therapy to poor responders during a controlled ovarian hyperstimulation (COH) cycle. Prospective clinical study. University hospital, general hospital, and private IVF clinic in Japan. Thirty normogonadotropic patients who did not respond to conventional COH protocols. Eight million units of recombinant human CSF-1 were administered IV every other day during ovarian stimulation using FSH or hMG to 30 normogonadotropic poor responders. Serum CSF-1 concentrations were assayed on day 3. Additional studies were performed in a private IVF clinic on 27 poor responders with low serum CSF-1 levels. Pregnancy rates (PR). In addition, number of mature follicles, cycle cancellations, amount of required gonadotropins were documented. Significantly more mature follicles, fewer cycle cancellations, and lower amounts of required gonadotropins were seen in the group treated with CSF-1. Five (16.7%) pregnancies were achieved. The CSF-1-effective patients displayed significantly lower serum CSF-1 concentrations. In a private IVF clinic, CSF-1 treatment increased the number of mature oocytes, fertilized eggs, and transferred embryos. Cycle cancellations decreased from 18.5%-3...Continue Reading

References

Sep 1, 1992·Journal of Reproduction and Fertility·Y FukumatsuH Okamura
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R K AssoianM B Sporn
Jun 5, 1987·Science·S C Clark, R Kamen
Jul 1, 1995·Journal of Reproduction and Fertility·K NishimuraH Okamura
Jan 1, 1996·Hormone Research·H KatabuchiH Okamura
Jan 1, 1997·Molecular Reproduction and Development·E R StanleyY G Yeung
Jan 1, 1997·Molecular Reproduction and Development·J W Pollard
May 1, 1997·British Journal of Obstetrics and Gynaecology·S D KeayJ M Jenkins
Aug 1, 1997·Fertility and Sterility·B R Witt, J W Pollard
Jan 9, 1998·British Journal of Obstetrics and Gynaecology·A GorgyI L Craft
Mar 18, 2003·Human Reproduction Update·B C TarlatzisJ Bontis

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Citations

Feb 18, 2011·Fertility and Sterility·Norbert GleicherDavid H Barad
Jan 15, 2015·American Journal of Reproductive Immunology : AJRI·Judit Svensson-Arvelund, Jan Ernerudh
Aug 27, 2013·Organogenesis·Christina V Jones, Sharon D Ricardo
Oct 30, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Song XuJian Huang
Feb 20, 2018·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Maryam EftekharParisa Khani
Sep 10, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Hulusi Bulent ZeynelogluUtkun Moran

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