Clinical Use of Placebo Effects in Patients With Pain Disorders

International Review of Neurobiology
Regine KlingerLuana Colloca

Abstract

The analgesic placebo effect is well documented by numerous studies. Many important influencing factors, however, are yet to be discovered. In the arena of placebo effects and clinical implications, expectancies play a central role. Expectancies are shaped by processes of classical and social learning as well as verbal instructions and are strongly related to emotional factors. Expectancies trigger a cascade of endogenous opioids and non-opioids, which alter the experience of pain. For clinical application it is important to know, that placebo research yields ethical possibilities to use placebo effects without deception and without using placebos. Since placebo effects contribute to responses to active analgesics, it is feasible to enhance patients' benefits from pain treatments by increasing the additional placebo effect. There are several possibilities to use the placebo effects via shaping and adapting information about analgesic medication and via associating medication intake with a positive context. A positive patient-clinician communication atmosphere is very important to generate clinically meaningful placebo effects in pain medicine.

Citations

Jun 26, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sanjivan Kandasamy, Charles S Greene
Dec 2, 2020·European Journal of Anaesthesiology·Michael MeißnerAlexander Schnabel
Mar 5, 2021·Journal of Pain Research·Xiao ZhangFengchun Zhang
Nov 2, 2020·Pain Practice : the Official Journal of World Institute of Pain·Marnin Joseph RommLawrence Patrick Cahalin
May 14, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jean SelimVincent Compere
Apr 25, 2021·Clinical Pharmacology and Therapeutics·Ariane SölleRegine Klinger
May 30, 2021·European Journal of Pain : EJP·Johan Hans Peter Alexander van LennepKarolina Maria Szadek
Oct 20, 2020·Psychotherapy and Psychosomatics·Andrea W M EversUNKNOWN Consortium of Placebo Experts
Jan 9, 2022·The Australian and New Zealand Journal of Psychiatry·Masoud Ahmadzad-AslAhmadreza Shamshiri
Jan 11, 2022·The American Journal of Clinical Hypnosis·Antonella Ciaramella

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