Oct 1, 1989

Clinical use of prostate specific antigen in patients with prostate cancer

The Journal of Urology
M A HudsonW J Catalona


The clinical use of prostate specific antigen as a screening test for prostate cancer, as a preoperative determinant for staging of prostate cancer and to monitor response to therapy in prostatic cancer patients was evaluated in 168 men with benign prostatic hyperplasia and 231 men with prostate cancer. Only 3% of the men with benign prostatic hyperplasia had prostate specific antigen levels greater than 10 ng. per ml. compared to 44% of the men with proved prostate cancer. Preoperative prostate specific antigen levels increased with higher clinical stages of prostate cancer but there was substantial overlap among stages. Among patients with stage A1 prostate cancer who were followed expectantly none had an elevated prostate specific antigen value or metastatic disease during a followup of 15 to 120 months. After radical prostatectomy serum prostate specific antigen values decreased to undetectable levels (less than 0.6 ng. per ml.) in 89% of the patients with organ-confined disease, in 87% of those with microscopically positive margins only but in only 34% with seminal vesicles or lymph node involvement. Failure of the prostate specific antigen levels to decrease to the undetectable range after radical prostatectomy was associ...Continue Reading

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Mentioned in this Paper

Prostatic Neoplasms
Acid Phosphatase
Neoplasm Recurrence, Local
Dermatofibrosarcoma Protuberans
TNM Staging System
Benign Prostatic Hypertrophy
Prostatectomy, Suprapubic
Recurrent Tumor
Tumor Markers
Prostate Carcinoma

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