Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort

Mediators of Inflammation
Anja Ten BrinkeEva Martínez-Cáceres

Abstract

The number of patients with autoimmune diseases and severe allergies and recipients of transplants increases worldwide. Currently, these patients require lifelong administration of immunomodulatory drugs. Often, these drugs are expensive and show immediate or late-occurring severe side effects. Treatment would be greatly improved by targeting the cause of autoimmunity, that is, loss of tolerance to self-antigens. Accumulating knowledge on immune mechanisms has led to the development of tolerogenic dendritic cells (tolDC), with the specific objective to restrain unwanted immune reactions in the long term. The first clinical trials with tolDC have recently been conducted and more tolDC trials are underway. Although the safety trials have been encouraging, many questions relating to tolDC, for example, cell-manufacturing protocols, administration route, amount and frequency, or mechanism of action, remain to be answered. Aiming to join efforts in translating tolDC and other tolerogenic cellular products (e.g., Tregs and macrophages) to the clinic, a European COST (European Cooperation in Science and Technology) network has been initiated-A FACTT (action to focus and accelerate cell-based tolerance-inducing therapies). A FACTT aims...Continue Reading

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Citations

May 22, 2016·Journal of Neuroinflammation·María José MansillaEva María Martínez-Cáceres
Oct 25, 2016·Autoimmunity Reviews·Paulina García-GonzálezJuan Carlos Aguillón
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Jul 12, 2019·Frontiers in Immunology·Juan Navarro-BarriusoEva M Martínez-Cáceres
Apr 18, 2020·Expert Opinion on Biological Therapy·Cristian LoretelliPaolo Fiorina
Mar 12, 2019·Frontiers in Immunology·Anja Ten BrinkeEva Martinez-Caceres
Aug 29, 2017·Immunologic Research·Grace E Esebanmen, William H R Langridge
Jul 17, 2020·Frontiers in Immunology·Xiaoxiao DuZhonghua Klaus Chen
Nov 3, 2020·Frontiers in Immunology·Laura Passerini, Silvia Gregori
Nov 10, 2020·Frontiers in Immunology·Weitao QueXiao-Kang Li
Oct 5, 2021·Frontiers in Immunology·Aarón Vázquez-JiménezOsbaldo Resendis-Antonio

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Methods Mentioned

BETA
nuclear

Software Mentioned

MITAP
FACTT

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