PMID: 3973267Mar 1, 1985

Clinical use of ultrashort-lived radionuclide krypton-81m for noninvasive analysis of right ventricular performance in normal subjects and patients with right ventricular dysfunction

Journal of the American College of Cardiology
C A NienaberW H Bleifeld

Abstract

The ultrashort-lived radionuclide krypton-81m, eluted in 5% dextrose from a bedside rubidium-81m generator, was intravenously infused for rapid imaging of the right-sided heart chambers in the right anterior oblique projection adjusted for optimal right atrioventricular separation. Left-sided heart and lung background was minimized by rapid decay and efficient exhalation of krypton-81m, requiring no algorithm for background correction. A double region of interest method decreased the variability in the assessment of ejection fraction to 5%. In 10 normal subjects, 11 patients with pulmonary hypertension, 4 patients with right ventricular outflow tract obstruction and 4 patients with right ventricular infarction, right ventricular ejection fraction determined by krypton-81m equilibrium blood pool imaging ranged from 14 to 76%. The correlation between these values and those determined by cineangiography according to Simpson's rule was close: r = 0.93 for all data points (p less than 0.001), r = 0.92 for studies at rest (p less than 0.001) and r = 0.93 for exercise studies (p less than 0.001). Exercise-related changes in right ventricular function revealed a disturbed functional reserve with pulmonary hypertension and right ventric...Continue Reading

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Citations

Dec 1, 1993·International Journal of Cardiac Imaging·R M OliverD G Waller
Jan 1, 1997·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·K NicholsA Rozanski
Jan 1, 1987·Pediatric Cardiology·M S SchafferV Rose
Jun 1, 1991·Clinical Cardiology·E PattersonR Lazzara

Related Concepts

Cineangiography
Half-Life
Heart Diseases
Left Ventricular Structure
Hemodynamics
Pulmonary Hypertension
Krypton
Pulmonary Stenosis
Radioisotopes
Stroke Volume

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