Clinical Usefulness of ¹⁸F-FDG PET/CT for the Detection of Infections of Unknown Origin in Patients Undergoing Maintenance Hemodialysis

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Jing-Ren TsengTzu-Chen Yen

Abstract

Patients with end-stage renal disease undergoing maintenance hemodialysis (MHD) are highly prone to infections. The potential clinical usefulness of (18)F-FDG PET/CT for the detection of infections of unknown origin in this patient population remains unclear. This study was designed to investigate this issue. Between October 2011 and July 2014, a total of 104 adult MHD patients with sepsis underwent (18)F-FDG PET/CT for the detection of unknown infection foci. Follow-up was continued until October 2014. Positive (18)F-FDG PET/CT findings and mortality served as the main outcome measures. Of the 104 study patients, 73 (70.2%) had positive (18)F-FDG PET/CT findings, and a total of 95 major infection foci were identified. Eighteen patients (24.6%) had at least 2 infection foci on (18)F-FDG PET/CT scans. Seven (53.8%) of the 13 patients with primary vascular access-related infections had concurrent metastatic foci. Twenty-eight patients (26.9%) had their treatments modified by (18)F-FDG PET/CT results. Multivariate logistic regression analysis demonstrated that low hemoglobin and high C-reactive protein levels at diagnosis were the independent predictors of positive (18)F-FDG PET/CT results. Twenty-seven patients (26.0%) died durin...Continue Reading

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Citations

Sep 28, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Chih-Hsing WanTzu-Chen Yen
Aug 24, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William F WrightPhilip A Mackowiak
Mar 31, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andor W J M GlaudemansGooitzen M van Dam
Jul 1, 2021·Nature Reviews. Nephrology·Barbara M KlinkhammerPeter Boor
Mar 21, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Reyhan Bilici SalmanMehmet Akif Öztürk

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