PMID: 7544482Jan 1, 1995Paper

Clinical usefulness of free and complexed PSA

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
A F Prestigiacomo, T A Stamey

Abstract

We selected serums from 51 fully characterized prostate cancer patients and 48 biopsy-proven BPH patients in order to test the ability of the ratio of the free/total PSA in distinguishing between CaP and BPH patients in the best case scenario. The 51 cancer patients had cancer volumes ranging from 2.0-17.8 mL and had a median % free PSA of 8.9%. The 48 BPH patients, which had prostate volumens ranging from 36.9-313.8 mL, had a median % free PSA of 16.5%, almost twice that of the CaP patients. We also examined the physiological variation of serums drawn on the same patient over a reasonably short time (mean of 22 days). The variation between consecutive redraws on the same patient was measured to be 30% (95% confidence interval) in the PSA range of 4-10 micrograms/L, measured on the Hybritech Tandem-R PSA Assay.

Citations

Jul 29, 1996·International Journal of Cancer. Journal International Du Cancer·C StephanS A Loening
Feb 3, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·M VoglW Höltl
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F EspañaJ F Jiménez-Cruz
Jan 6, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·H MatsuyamaK Naito
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tujin ShiWei-Jun Qian
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
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Apr 16, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·M KuriyamaJ Shimazaki
May 1, 1997·The Urologic Clinics of North America·L J Sokoll, D W Chan

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