Clinical usefulness of Glycated Albumin in the diagnosis of diabetes: Results from an Italian study.

Clinical Biochemistry
Chiara BelliaMarcello Ciaccio

Abstract

Glycated Albumin (GA) has been proposed as a screening marker for diabetes in Asian countries in the last years. Nevertheless, few studies have been conducted in Caucasian population. The aim of this study is to evaluate the clinical usefulness of GA in diabetes diagnosis in Caucasian asymptomatic subjects considered at risk of diabetes based on medical history and Fasting Plasma Glucose (FPG). Three hundred and thirty-four Caucasian subjects having one or more risk factor for diabetes, and/or FPG ranging from 5.6 mmol/L to 6.9 mmol/L with no symptoms for diabetes were enrolled in this study. Plasma GA was measured by an enzymatic method (quantILab Glycated Albumin) on ILab Taurus instrument (Instrumentation Laboratory - A Werfen Company). GA median levels were 13.2% (IQR:12.2-14.4). Eighteen subjects (5.4%) were classified as diabetics based on their HbA1c. According to the ROC curve analysis, GA identified subjects with diabetes with a sensitivity of 72.2% (95% CI: 46.5-90.3) and a specificity of 71.8% (95% CI: 66.5-76.7) (AUC: 0.80; 95% CI: 0.75-0.84; P < 0.0001) at the cut-off of 14%. The cut-off of 13.5% was associated to a higher sensitivity 88.9% (95%CI: 65.3-98.6) and a specificity of 60.4% (95%CI, 54.8-65.9). This stud...Continue Reading

Citations

May 10, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Chiara BelliaMarcello Ciaccio
Jan 1, 2020·PloS One·Fernando Chimela ChumeJoíza Lins Camargo
Dec 29, 2018·Biochemia Medica·Graziella BonettiFerruccio Ceriotti
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Nov 18, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mustapha Zendjabil
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Apr 24, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Rosaria Vincenza GiglioManfredi Rizzo
May 3, 2021·Diabetology & Metabolic Syndrome·Rui WangWenchao Hu
May 15, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Luisa AgnelloMarcello Ciaccio
May 23, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nasheeta PeerAndre-Pascal Kengne
Jun 1, 2021·Computational and Mathematical Methods in Medicine·Xiue GaoShengbin Zhou
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Jul 27, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shin AleksKabytaev Kuanysh

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