PMID: 8962760Aug 1, 1996Paper

Clinical usefulness of the determination of the lipase/elastase ratio and of the polymorphonuclear elastase in the hospital admission of the patient with acute pancreatitis

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
L LuengoC Olona

Abstract

The clinical usefulness of the determination of polymorphonuclear elastase in serum, in patients with acute pancreatitis as a predictive value of severity. A prospective study was made of 60 patients who at admission in the hospital showed high rates not only of lipase but also of polymorphonuclear elastase. High rates of this enzyme have been statistically related with the severity of pancreatitis. This severity is expressed by multifactorial Glasgow prognostic factors and by Ranson's CT degree. The predictive value in the evolution of the disease has been related to the need for surgery and related to the number of hospitalization days in non-operated patients. All these factors have been analysed taking into account such variables as age, sex, and biliary origin of the acute pancreatitis. Our study shows no statistically significant correlation between high polymorphonuclear (pmn) elastase serum levels in patients with acute pancreatitis (AP) and their evolution (as evaluated by means of clinical signs and CT images). In other words, determination of high pmn elastase serum levels has no predictive value to indicate the degree of severity in AP. Finally, we have found no clinical use in the lipase/ amylase ratio, neither as ...Continue Reading

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