PMID: 6103690Jan 1, 1980Paper

Clinical usefulness of the simultaneous localisation of the isoenzymes of alkaline phosphate and gamma-glutamyl transferase

Annals of Clinical Biochemistry
M Baines

Abstract

Simultaneous localisation of the isoenzymes of alkaline phosphatase and gamma-glutamyl transferase was carried out on 173 serum samples from patients with hepatobiliary and bone disease to determine (i) if a better discrimination of the underlying pathology could be obtained by such an approach, and (ii) if the pathology suggested by the alkaline phosphatase isoenzyme separation could help in determining the cellular location of the gamma-glutamyl transferase isoenzymes. It was found that the localisation of the gamma-glutamyl transferase isoenzymes had, with a few exceptions, little advantage over the measurement of the total activity but that some evidence concerning the cellular location of the gamma-glutamyl transferase isoenzymes could be gained by such an approach. There was support for the view that the alpha 2-migrating isoenzyme is derived from the liver parenchymal cytoplasm, but little support for the view that the alpha 1-migrating isoenzyme is predominantly the induced microsomal enzyme or that the beta-migrating isoenzyme is the result of impaired biliary secretion.

References

Aug 4, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·O HetlandT Gerner
Mar 15, 1973·Klinische Wochenschrift·E B IgartuaJ Findor
Nov 23, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Patel, P O'Gorman
Jan 24, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·O Azzopardi, M F Jayle
May 1, 1974·Journal of Clinical Pathology·C P Price, H G Sammons
Feb 1, 1965·Clinica Chimica Acta; International Journal of Clinical Chemistry·F KOKOT, J KUSKA

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