Clinical utility of chromogranin A and octreotide in large cell neuro endocrine carcinoma of the uterine corpus.

Rare Tumors
Shohreh ShahabiGary L Goldberg

Abstract

Primary neuroendocrine tumors of the female genital tract have been described in the cervix, ovaries and uterus. Large cell neuroendocrine carcinoma (LCNC) of the uterine corpus is the least common and appears to behave the most aggressively. We report a rare case of a large cell neuroendocrine tumor of the endometrium. These tumors are not well characterized, unlike neuroendocrine tumors of the uterine cervix. Consequently, the optimal management remains still unclear. The treatment of our case consisted of surgery, radiotherapy, chemotherapy, and octreotide. Despite the aggressive treatment, the patient died of disease progression 12 months after the initial diagnosis. We discuss the diagnosis, prognosis, and treatment options for LCNC of the genital tract, and potential future therapeutics.

References

Jan 1, 1984·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R E ScullyR A DeLellis
Jan 1, 1996·Current Opinion in Oncology·A Chaudhry, L Kvols
Aug 1, 1997·The American Journal of Surgical Pathology·C B GilksP B Clement

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Citations

Mar 6, 2016·The American Journal of Surgical Pathology·Cady E PocrnichAnais Malpica
Sep 4, 2020·BMJ Case Reports·Liesel Elisabeth HardyChloe Ayres
Jan 26, 2016·The Journal of Obstetrics and Gynaecology Research·Harunobu MatsumotoHaruto Nishida
Apr 13, 2019·Gynecologic Oncology Reports·Courtney JennyJonathan Boone
Nov 17, 2020·Rare Tumors·Grant BurkeenSusanne Arnold
May 3, 2021·Critical Reviews in Oncology/hematology·Giuseppe CarusoInnocenza Palaia
May 19, 2021·World Journal of Clinical Cases·Ran DuYing Du

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Methods Mentioned

BETA
biopsy
hysterectomy
light microscopy

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