Clinical Utility of Electronic Alberta Stroke Program Early Computed Tomography Score Software in the ENCHANTED Trial Database

Stroke; a Journal of Cerebral Circulation
S NagelENCHANTED Investigators

Abstract

Clinical utility of electronic Alberta Stroke Program Early CT Score (e-ASPECTS), an automated system for quantifying signs of infarction, was evaluated in a large database of thrombolyzed patients with acute ischemic stroke. All baseline noncontrast computed tomographic scans of patients with anterior circulation acute ischemic stroke who participated in the alteplase dose arm of the randomized controlled trial ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) were reviewed; poor quality and large (>6 mm) slice thickness were excluded. Included scans had e-ASPECTS scores correlated with baseline neurological severity (National Institutes of Health Stroke Scale scores) and 90-day disability outcomes (modified Rankin Scale scores). Multivariable logistic regression models were used to determine the predictive ability of e-ASPECTS for disability outcomes and symptomatic intracranial hemorrhage. Of 2426 available computed tomographic images, 1480 (61%) were included in analyses of e-ASPECTS scores (median 9 [interquartile range, 8-10], 77% with good [range, 8-10] scores). Lower e-ASPECTS scores (per 1-point decrease) were significantly associated with increasing baseline National Institutes of Health Strok...Continue Reading

References

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Citations

Oct 2, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Simon NagelIris Q Grunwald
Oct 9, 2019·Journal of Neurointerventional Surgery·Nick M MurrayFerdinand K Hui
Jul 29, 2019·Journal of Neurointerventional Surgery·Jan Christoph PurruckerChristoph Gumbinger
Dec 11, 2019·Journal of Neurointerventional Surgery·Ain NeuhausWaleed Brinjikji
Dec 20, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Hulin KuangUNKNOWN INTERRSeCT Collaborators
Sep 25, 2019·Stroke; a Journal of Cerebral Circulation·Sunil A ShethLuca Giancardo
Dec 18, 2020·Arquivos de neuro-psiquiatria·Lucas Andrade FerretiMarcos Christiano Lange
Aug 15, 2019·Neurological Research and Practice·Yahia MokliSimon Nagel
Feb 26, 2021·Stroke; a Journal of Cerebral Circulation·Charlotte S WeylandSimon Nagel
Mar 8, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Paul MikhailGrant Mair
Apr 16, 2021·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Waleed BrinjikjiDavid F Kallmes
Apr 21, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Masaki NaganumaToshiro Yonehara
Jun 13, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Mehdi BouslamaRaul G Nogueira

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