Clinical Utility of FDG PET/CT in Patients with Autoimmune Pancreatitis: a Case-Control Study

Scientific Reports
Mei-Fang ChengHsiu-Po Wang

Abstract

Autoimmune pancreatitis (AIP) shares overlapping clinical features with pancreatic cancer (PC). Importantly, treatment of the two conditions is different. We investigated the clinical usefulness of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with suspected AIP before treatment. From September 2008 to July 2016, 53 patients with suspected AIP at National Taiwan University Hospital had PET/CT prior to therapy to exclude malignancy and evaluate the extent of inflammation. Their scans were compared with those from 61 PC patients. PET imaging features were analyzed using logistic regression. Significant differences in pancreatic tumor uptake morphology, maximum standardized uptake value, high-order primary tumor texture feature (i.e. high-gray level zone emphasis value), and numbers and location of extrapancreatic foci were found between AIP and PC. Using the prediction model, the area under curve of receiver-operator curve was 0.95 (P < 0.0001) with sensitivity, specificity, positive predictive, and negative predictive values of 90.6%, 84.0%, 87.9%, and 87.5% respectively, in differentiating AIP from PC. FDG PET/CT offers high sensitivity, albeit slightly lower specificity in d...Continue Reading

References

Mar 10, 2001·The New England Journal of Medicine·H HamanoK Kiyosawa
Nov 14, 2003·Journal of Gastroenterology·Terumi KamisawaHitoshi Nakajima
Dec 23, 2006·Gastrointestinal Endoscopy·Takahiro NakazawaTakashi Joh
Aug 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Masatoyo NakajoMasayuki Nakajo
Jun 18, 2009·The American Journal of Gastroenterology·Amit RainaAdam Slivka
Aug 18, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hiroyuki MatsubayashiHiroyuki Ono
Dec 3, 2010·Current Opinion in Rheumatology·Arezou Khosroshahi, John H Stone
Mar 18, 2011·Pancreas·Tooru ShimosegawaUNKNOWN International Association of Pancreatology
Jun 14, 2012·International Journal of Rheumatology·Jay H RyuEunhee S Yi
Jan 16, 2013·The American Journal of Gastroenterology·Masahiro ShiokawaTsutomu Chiba
Oct 19, 2013·Scandinavian Journal of Rheumatology·H ChenF Zhang
Feb 5, 2014·Internal Medicine·Kenji HiranoKazuhiko Koike
Mar 22, 2014·Annals of the Rheumatic Diseases·Mollie N CarruthersJohn H Stone
Apr 26, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Jingjing ZhangZhaohui Zhu
Oct 4, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Ming-Chu ChangYu-Ting Chang
Feb 11, 2015·Annals of the Rheumatic Diseases·Mollie N CarruthersJohn H Stone
Mar 27, 2015·Arthritis & Rheumatology·A KhosroshahiUNKNOWN Second International Symposium on IgG4-Related Disease
Apr 18, 2015·Medicine·Dai InoueYoh Zen
May 20, 2015·Arthritis & Rheumatology·Zachary S WallaceJohn H Stone
Jul 5, 2015·Mayo Clinic Proceedings·John H StoneManuel Ramos-Casals
Nov 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Fanny OrlhacIrène Buvat

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Citations

Jun 15, 2018·Current Opinion in Gastroenterology·Nicolò de PretisLuca Frulloni
Sep 29, 2019·Abdominal Radiology·Kunal KothariFrank H Miller
Aug 21, 2019·Abdominal Radiology·Anushri Parakh, Temel Tirkes
Sep 18, 2020·Nature Reviews. Rheumatology·Cory A Perugino, John H Stone
Jul 29, 2020·Gastroenterología y hepatología·Diego Federico BaenasSergio Paira
Jun 22, 2021·Current Opinion in Gastroenterology·Temel TirkesEvan L Fogel
Aug 24, 2021·Clinical Hemorheology and Microcirculation·Janine RennertErnst Michael Jung
Apr 3, 2020·La Presse médicale·Vinciane Rebours, Philippe Lévy
Sep 1, 2021·Rheumatology·Manil SubesingheSujith Subesinghe
Nov 9, 2021·Annals of Nuclear Medicine·Ken NagahataHiroki Takahashi

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Methods Mentioned

BETA
biopsies
biopsy
surgical resection

Software Mentioned

JMP®
HGLZE
eNTEGRA

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