Clinical Utility of Fecal Calprotectin Monitoring in Asymptomatic Patients with Inflammatory Bowel Disease: A Systematic Review and Practical Guide

Inflammatory Bowel Diseases
Anke HeidaPatrick F van Rheenen

Abstract

In asymptomatic patients with inflammatory bowel disease (IBD), "monitoring" involves repeated testing aimed at early recognition of disease exacerbation. We aimed to determine the usefulness of repeated fecal calprotectin (FC) measurements to predict IBD relapses by a systematic literature review. An electronic search was performed in Medline, Embase, and Cochrane from inception to April 2016. Inclusion criteria were prospective studies that followed patients with IBD in remission at baseline and had at least 2 consecutive FC measurements with a test interval of 2 weeks to 6 months. Methodological assessment was based on the second Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) checklist. A total of 1719 articles were identified; 193 were retrieved for full text review. Six studies met eligibility for inclusion. The time interval between FC tests varied between 1 and 3 months. Asymptomatic patients with IBD who had repeated FC measurements above the study's cutoff level had a 53% to 83% probability of developing disease relapse within the next 2 to 3 months. Patients with repeated normal FC values had a 67% to 94% probability to remain in remission in the next 2 to 3 months. The ideal FC cutoff for monitoring cou...Continue Reading

References

Sep 1, 1992·Scandinavian Journal of Gastroenterology·A G RøsethH Schjønsby
Mar 8, 1980·Lancet·R F Harvey, J M Bradshaw
Oct 15, 1998·Gut·R S WalmsleyR N Allan
Jul 20, 2002·Inflammatory Bowel Diseases·Hester J LoonenHugo S A Heymans
Mar 19, 2005·BMJ : British Medical Journal·Paul GlasziouDavid Mant
May 28, 2005·BMC Medical Research Methodology·Penny WhitingJos Kleijnen
Mar 1, 2008·Alimentary Pharmacology & Therapeutics·N Westwood, S P L Travis
Mar 25, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R Berni CananiR Troncone
Sep 19, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jennifer JonesWilliam J Sandborn
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Feb 22, 2012·Inflammatory Bowel Diseases·Geert D'HaensPaul Rutgeerts
Aug 30, 2012·The American Journal of Gastroenterology·Stephen J Halpin, Alexander C Ford
Feb 5, 2013·Inflammatory Bowel Diseases·Jan DäbritzDirk Foell
Mar 2, 2013·Scandinavian Journal of Gastroenterology·Hans Linde NielsenHenrik Nielsen
Apr 9, 2013·Journal of Crohn's & Colitis·Pavol PapayRemo Panaccione
May 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mark T OstermanUNKNOWN DEAR Investigators
May 31, 2014·Inflammatory Bowel Diseases·Aranzazu Jauregui-AmezagaMaría Pellise
Jun 20, 2014·Canadian Journal of Gastroenterology & Hepatology·Mayur Brahmania, Charles N Bernstein
Jul 2, 2014·Inflammatory Bowel Diseases·Jin-Feng LinBo Jiang
Jun 9, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Klaus TheedeAnette Mertz Nielsen
Aug 26, 2015·The American Journal of Gastroenterology·L Peyrin-BirouletJ-F Colombel
Aug 11, 2016·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Anke HeidaPatrick F van Rheenen

❮ Previous
Next ❯

Citations

Jun 14, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anke HeidaPatrick F van Rheenen
Nov 15, 2017·Journal of Pediatric Gastroenterology and Nutrition·Karen QuelizaRichard Kellermayer
Jun 29, 2018·Pediatric Dermatology·Samantha L SchneiderTor Shwayder
May 3, 2018·Inflammatory Bowel Diseases·Seema A Patil, Raymond K Cross
Jul 24, 2018·Allergy·Eliete Neves Silva GuerraHélène Chardin
Sep 14, 2018·European Journal of Gastroenterology & Hepatology·Julian EssmannOliver Bachmann
Aug 24, 2018·Journal of Crohn's & Colitis·Christian MaaserUNKNOWN European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR
Jan 22, 2019·Journal of Pediatric Gastroenterology and Nutrition·Jiri BronskyAlmuthe Christina Hauer
Apr 2, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Daniela BassoMario Plebani
May 12, 2020·Journal of Crohn's & Colitis·Ferdinando D'AmicoLaurent Peyrin-Biroulet
Jul 17, 2020·Scandinavian Journal of Gastroenterology·Kaija-Leena Kolho, Henrik Alfthan
Aug 18, 2017·Inflammatory Bowel Diseases·K T ParkPatrick F van Rheenen
Sep 11, 2018·World Journal of Gastroenterology : WJG·Maria Gloria MumoloFrancesco Costa
May 8, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Andrea PadoanDaniela Basso
Feb 21, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Emilio J Laserna-Mendieta, Alfredo J Lucendo
Nov 22, 2019·World Journal of Gastroenterology : WJG·Lorant GoncziPeter Laszlo Lakatos
Feb 13, 2020·F1000Research·Simon P Borg-BartoloRahul Kalla
Aug 9, 2020·Inflammatory Bowel Diseases·Nienke Z BorrenAshwin N Ananthakrishnan
Mar 20, 2019·World Journal of Gastroenterology : WJG·Alice Jane FosterKevan Jacobson
May 16, 2019·Critical Reviews in Clinical Laboratory Sciences·Amanda Ricciuto, Anne M Griffiths
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Christopher MaBrian Gordon Feagan
Aug 9, 2020·Paediatrics & Child Health·Marta Velasco Rodríguez-BelvísRosa Ana Muñoz Codoceo
Apr 14, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Dharshan SathananthanRobert V Bryant
Oct 8, 2020·Journal of Crohn's & Colitis·Patrick F van RheenenFrank M Ruemmele
Nov 27, 2020·Scientific Reports·María RocaCarmen Ribes-Koninckx
Dec 12, 2020·Pharmacogenomics·Bianca Jc van den Bosch, Marieke Jh Coenen
Mar 16, 2019·Gastroenterology·Lindsey AlbenbergJames D Lewis
Mar 10, 2018·The Journal of Pediatrics·Warapan NakayuenyongsukK T Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.