Clinical utility of genetic risk testing in primary care: the example of Type 2 diabetes

Personalized Medicine
Allison VorderstrasseGeoffrey S Ginsburg

Abstract

Genetic advances in Type 2 diabetes (T2D) have led to the discovery and validation of multiple markers for this complex disease. Despite low predictive value of current T2D markers beyond clinical risk factors and family history, researchers are exploring the clinical utility and outcomes of implementation in practice, and testing is available via direct-to-consumer markets. Clinical utility research demonstrates high hypothetical utility to patients for motivating behavior change and potentially reducing risk. However, trials to date have not demonstrated improvements in behavioral and clinical outcomes over and above counseling based on traditional risk factors. Ongoing research in T2D genetics and associated risk-prediction models is necessary to refine genetic risk pathways, algorithms for risk prediction and use of this information in clinical care. Further research is also needed to explore care models and support interventions that address the needs of personalized risk information and sustainable preventive behaviors to reduce the rising prevalence of T2D.

Associated Clinical Trials

References

Jun 25, 2004·American Journal of Medical Genetics. Part a·Theresa MarteauUNKNOWN Genetic Risk Assessment for FH Trial Study Group
Feb 24, 2006·PLoS Medicine·A Cecile J W JanssensSubramony Subramonia-Iyer
May 30, 2006·Journal of Psychosomatic Research·Elizabeth BroadbentJohn Weinman
Dec 19, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Susan HaririMuin J Khoury
Jun 16, 2007·PLoS Medicine·Valeriya LyssenkoUNKNOWN Botnia Study Group
Jun 24, 2008·The American Journal of Bioethics : AJOB·Wylie BurkeNancy Press
Oct 15, 2008·Human Molecular Genetics·A Cecile J W Janssens, Cornelia M van Duijn
Nov 1, 2008·Novartis Foundation Symposium·Stephen P Robertson, Richie Poulton
Apr 29, 2009·Journal of Transcultural Nursing : Official Journal of the Transcultural Nursing Society·Barbara Burns McGrath, Karen L Edwards
May 20, 2009·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Linda D CameronPaul M Brown
Jul 21, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Muin J KhouryUNKNOWN Centers for Disease Control and Prevention
Jul 29, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Raluca MihaescuA Cecile J W Janssens
Feb 11, 2010·Journal of Diabetes Science and Technology·Rodolfo Valdez
May 4, 2010·Lancet·Euan A AshleyRuss B Altman
Dec 15, 2010·The New England Journal of Medicine·Mark I McCarthy
Jan 14, 2011·The New England Journal of Medicine·Cinnamon S BlossEric J Topol
Feb 1, 2011·PLoS Currents·Raluca MihaescuA Cecile Janssens
Dec 27, 2011·Personalized Medicine·Cinnamon S BlossEric J Topol
Jan 17, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Jason L VassyRichard W Grant
Jan 21, 2012·BMC Medical Genomics·Eline M BunnikA Cecile J W Janssens
Mar 21, 2012·Annals of Internal Medicine·Mark A Hlatky
Jul 24, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S PrudenteV Trischitta
Jul 26, 2012·BMC Genomics·Jonathan M DreyfussMarco F Ramoni
Aug 14, 2012·Nature Genetics·Andrew P MorrisUNKNOWN DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Nov 7, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Shoshana ShilohBarbara B Biesecker
Feb 15, 2013·Genetic Testing and Molecular Biomarkers·Susanne B HagaHuntington F Willard
Feb 26, 2013·Journal of Community Genetics·Jason L VassyRichard W Grant

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Citations

Jun 23, 2018·Personalized Medicine·Susan PerskyRachel W Cohen
May 6, 2014·Journal of Nutrition and Metabolism·N M R SalesM C Goersch
May 1, 2016·Personalized Medicine·Emily K CheeraMee Young Hong
Jan 1, 2014·Personalized Medicine·Sridharan Raghavan, Jason L Vassy
May 18, 2021·Primary Care Diabetes·Kathryn T DrazbaFernando Ovalle

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Methods Mentioned

BETA
blood drawn
pharmacotherapy

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