PMID: 7518726Jul 1, 1994Paper

Clinical utility of insulin-like growth factor binding protein-3 in the evaluation and treatment of short children with suspected growth hormone deficiency

European Journal of Endocrinology
Y HasegawaS Yokoya

Abstract

We have shown previously that serum insulin-like growth factor binding protein-3 (IGFBP-3) levels have good predictive value for complete, but not partial, growth hormone deficiency (GHD). In this study, we compare IGFBP-3 levels in short children previously divided into groups on the basis of their post-stimulation GH levels. Complete GHD (N = 59) included those children with peak post-stimulation GH < 5 micrograms/l. The partial GHD group (N = 49) had post-stimulation GH peaks of > 5 micrograms/l but < 10 micrograms/l. The normal children with short stature (N = 103) had post-stimulation GH peaks > 10 micrograms/l. Partial GHD and normal children with short stature also were divided into either low IGF-I or normal IGF-I subgroups. The clinical sensitivity of IGFBP-3 for complete GHD was 92%, whereas its sensitivity for partial GHD was 39%. For partial GHD, among those with low IGF-I (N = 19) 68% were also low for IGFBP-3, while 80% of those with normal IGF-I (N = 30) were also normal for IGFBP-3. The clinical specificity of IGFBP-3 for normal children with short stature was 69%. For these groups, among those with low IGF-I (N = 22) 73% also were low for IGFBP-3, while 80% of those with normal IGF-I (N = 81) also were normal f...Continue Reading

Citations

Jan 1, 1995·Progress in Growth Factor Research·Y HasegawaY Tsuchiya
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Mar 6, 2007·Endocrinology and Metabolism Clinics of North America·David R Clemmons
Jul 1, 1997·The Journal of Pediatrics·M A Preece
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P C SizonenkoZ Laron
Jul 1, 1995·Clinical Endocrinology·S CianfaraniB Boscherini
May 7, 1998·Endocrine Reviews·S M ShaletB M Brennan
Jul 1, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Fiorella GalluzziSalvatore Seminara
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·V TillmannP E Clayton
Sep 1, 1996·Developmental Medicine and Child Neurology·S J ConiglioA D Rogol
Jul 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·F ColonnaL Radillo
Jun 14, 2019·Hormone Research in Pædiatrics·Jan M WitUNKNOWN on behalf of the Dutch Working Group on Triage and Diagnosis of Growth Disorders in Children

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