PMID: 9549634Apr 29, 1998Paper

Clinical utility of long-term enalapril/diltiazem ER in stage 3-4 essential hypertension. Long-term Use of Enalapril/Diltiazem ER in Stage 3-4 Hypertension Group

Journal of Clinical Pharmacology
Steven G ChrysantR Goldstein

Abstract

The use of angiotensin converting enzyme inhibitors and calcium channel blockers, as monotherapies and in combination, is common in the management of hypertension. Clinical studies have documented the augmentation of blood pressure reduction when these agents are combined compared with the individual agents, in short-term studies. In the present investigation, 93 patients with stage 3-4 essential hypertension, who successfully completed a short-term double-blind study, participated in a 40-week open-label treatment phase. The patients were maintained on their previous doses of enalapril/diltiazem ER (E/D) with or without additional antihypertensive medications. Doses of medication could be adjusted as necessary for blood pressure control. Of the 93 patients, 68% were male and 82% were white; they averaged 52.7 years of age and had a baseline mean sitting blood pressure (SiBP) of 167/111 mmHg. The use of E/D alone (n = 14) reduced mean SiBP by 14.5/14.4 mmHg from baseline, whereas the use of E/ D with other agents (n = 79) decreased it by 27/20.5 mmHg from baseline. E/D alone or in combination with other drugs was well-tolerated, and no serious adverse events were noted. This long-term open-label study demonstrated that the E/D ...Continue Reading

References

Apr 1, 1992·American Heart Journal·J V FelicettaG D Park
Jan 1, 1992·Journal of Clinical Pharmacology·S G ChrysantC Steiner
Apr 17, 1989·The American Journal of Medicine·R EggertsenL Hansson
Jun 9, 1989·JAMA : the Journal of the American Medical Association·J A CramerV L Ouellette
Mar 1, 1985·Journal of Clinical Pharmacology·S G ChrysantM McPherson
Jan 1, 1986·Clinical Pharmacology and Therapeutics·W B WhiteS Podesla
Jan 1, 1986·American Journal of Nephrology·R PieriA Pirrelli
Jun 1, 1983·Clinical Pharmacology and Therapeutics·S G ChrysantJ L Brown
Jan 27, 1994·The American Journal of Cardiology·D Maclean

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Citations

Jul 8, 2003·Current Hypertension Reports·George S Chrysant, Steven G Chrysant
Sep 23, 2003·QJM : Monthly Journal of the Association of Physicians·S G Chrysant
Aug 14, 2009·Expert Review of Cardiovascular Therapy·Steven G Chrysant

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