PMID: 8950366Jan 1, 1996Paper

Clinical utility of measurements of free and total prostate-specific antigen (PSA): a review

The Prostate. Supplement
W J Catalona

Abstract

Prostate-specific antigen (PSA) is a widely-used tumor marker to aid in the early detection of prostate cancer. PSA testing has appreciable false-positive and false-negative results, particularly in the 2.5-10.0 ng/ml range. Measurements of the percentage of nonprotein-bound (free) PSA in serum, which is lower in patients with prostate cancer, has been evaluated as a method for increasing the accuracy of PSA testing. The literature on forms of PSA in serum, as it relates to issues of clinical utility for prostate cancer screening, was reviewed and summarized through May 1996. Measurements of the percentage of free PSA in serum increase the accuracy of PSA testing for prostate cancer in men whose total PSA levels are 2.5-10.0 ng/ml. Cutoffs for screening are affected by prostate volume and total PSA levels. One study also demonstrated a correlation between percentage of free PSA and pathologic features of cancer aggressiveness. Measurement of free PSA in serum has potential clinical utility for increasing the sensitivity and specificity of PSA screening. Insufficient data are available to establish cutoffs to be used in clinical practice. Cutoffs are affected by total PSA level and prostate volume. The prevalence rate of cancer ...Continue Reading

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Citations

Oct 26, 1999·BJU International·J J CartledgeI Eardley
Oct 23, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Wolfgang HerrmannJürgen Geisel
Dec 18, 2012·Periodontology 2000·Michael Mawhinney, Angelo Mariotti
Jul 1, 2016·Archives of Environmental & Occupational Health·Chinwe O EwenighiUchechukwu Ezeugwu
Jan 8, 1998·International Journal of Cancer. Journal International Du Cancer·A MeyerS A Loening
Oct 8, 2015·Irish Journal of Medical Science·J C FordeT H Lynch
May 9, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·F L TelloM D González
Dec 14, 2004·Journal of Molecular Recognition : JMR·Sandrine MichelColette Jolivet-Reynaud
Oct 6, 1998·Critical Reviews in Clinical Laboratory Sciences·H G RittenhouseA W Partin
Jan 1, 2010·Sensors·Young-Eun ChoiJoon Won Park
Aug 26, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·H MaedaS Maekawa

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