Clinical utility of serum amyloid A and macrophage migration inhibitory factor as serum biomarkers for the detection of nonsmall cell lung carcinoma

Cancer
Nayela KhanEdward F Patz

Abstract

Early lung carcinoma detection strategies involving imaging studies have yet to demonstrate a reduction in mortality. Identification of serum biomarkers that could complement radiologic studies and facilitate earlier diagnosis of lung carcinoma would be of significant benefit to patients. In the current pilot study, the authors evaluated two overexpressed proteins in lung carcinoma, serum amyloid A (SAA) and macrophage migration inhibitory factor (MIF), as potential diagnostic serum biomarkers for this malignancy. Serum levels of SAA and MIF were measured in 50 patients using enzyme-linked immunosorbent assays. The sensitivity, specificity, and accuracy of the markers in detecting lung carcinoma were determined. SAA levels in patients with lung carcinoma were greater than in the control patients (P = 0.07). Serum SAA levels did not exhibit a correlation with tumor size or clinical stage and were higher in patients with squamous cell carcinoma than in patients with other histologic disease types. MIF was unable to differentiate patients with lung carcinoma from patients with other diseases. SAA possesses potential utility as a serum biomarker for lung carcinoma, probably in conjunction with other serum markers that improve its d...Continue Reading

References

Aug 26, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A Ghossein, S Bhattacharya
Aug 30, 2000·Nature·C M PerouD Botstein
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y S ChangL L Munn
Apr 5, 2002·Microbes and Infection·Hongqi LueJürgen Bernhagen
Feb 6, 2003·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 26, 2003·Radiology·Stephen J SwensenMedy A Clemens
Aug 6, 2003·FEMS Immunology and Medical Microbiology·Elaine HatanakaAna Campa
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William C S ChoCadmon K P Lim

❮ Previous
Next ❯

Citations

Dec 13, 2006·Molecular Diagnosis & Therapy·John CopierAngus Dalgleish
Dec 17, 2008·World Journal of Surgery·Matthew A FirpoSean J Mulvihill
Jul 5, 2007·Science in China. Series C, Life Sciences·SongWei DaiDaCheng He
May 9, 2013·Public Health Nutrition·Zeinab KarimiBahram Rashidkhani
Sep 21, 2013·Public Health Nutrition·Brook E HarmonGertraud Maskarinec
Jan 31, 2014·Public Health Nutrition·Maryam RafrafMohammad Asghari Jafarabadi
Dec 24, 2005·Journal of the American College of Nutrition·Peter W Parodi
May 31, 2007·Current Opinion in Pulmonary Medicine·Alissa K Greenberg, M Sung Lee
Jan 26, 2011·The Cancer Journal·Susan C Van't Westeinde, Rob J van Klaveren
May 6, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John YeeStephen Lam
Apr 8, 2009·Proceedings of the American Thoracic Society·Sebahat OcakPierre P Massion
Oct 1, 2008·Biomarkers in Medicine·Sabine ClassenJoachim L Schultze
Feb 8, 2014·The British Journal of Nutrition·Lian WangCai-Xia Zhang
Mar 14, 2014·Journal of Aging Research·Göran NilssonJohn Ohrvik
Mar 28, 2013·Mediators of Inflammation·Franciele Hinterholz KnebelAna Campa
Mar 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William L BigbeeJill M Siegfried
Oct 3, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Pinar B YildizPierre P Massion
Jan 12, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Fatma Oz AtalayHakan Vuruskan
May 25, 2010·The Annals of Thoracic Surgery·Eric L GroganPierre P Massion
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Edward F Patz
Dec 8, 2010·Proteomics. Clinical Applications·Rosa PeracaulaPauline M Rudd
Jan 22, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Xiao-Chun NiShuang-Jian Qiu
May 4, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Beyhan OmerFigen Gurdol
Jul 20, 2010·Journal of Experimental & Clinical Cancer Research : CR·Jinhwa Lee, Sung Soo Kim
Jun 17, 2014·PloS One·Stephanie E BrockRobert A Mitchell
Jun 19, 2009·Trends in Endocrinology and Metabolism : TEM·Charles V ClevengerJiamao Zheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.