Clinical utility of sex hormone-binding globulin measurement

Hormone Research
Michel PugeatM G Forest

Abstract

The high-affinity binding of the sex hormone-binding globulin (SHBG) for testosterone and to a lesser extent for estradiol influences the circulating levels of these sex steroid hormones, their biodisposal to target cells as well as their mutual balance. Although the regulation of SHBG is still not completely understood, in vitro studies performed with human hepatocarcinoma (Hep G2) cells have shown that estrogens and thyroxine stimulate SHBG secretion, by increasing the steady state of its mRNA concentrations. These observations are in good agreement with studies showing that SHBG levels increase during oral administration of estrogens as well as in patients with thyrotoxicosis. Interestingly, SHBG levels are normal in syndromes such as the abnormal transport of thyroid hormones and/or the syndrome of thyroid hormone resistance, which can be confused with thyrotoxicosis. By contrast, the effects of androgens are controversial. In many patients with hirsutism, SHBG concentrations are low and correlate negatively with both body mass index and fasting insulin levels. Because of the inhibitory effect of both insulin and insulin-like growth factor-1 on SHBG secretion by Hep G2 cells in vitro, it has been proposed that SHBG levels c...Continue Reading

Citations

Apr 20, 2001·Calcified Tissue International·P GillbergS Ljunghall
Oct 13, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Andreas N SchüringMartin Götte
Jul 21, 2006·Wiener klinische Wochenschrift·Anton Staudenherz, Helmut Sinzinger
Nov 6, 1998·Disease-a-month : DM·W B Cutler, E Genovese-Stone
Feb 28, 2002·Journal of the Neurological Sciences·Alessandra MilitelloVincenzo La Bella
Sep 8, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Edith C H FriesemaTheo J Visser
Jul 12, 2002·Journal of the American Geriatrics Society·Maria Clara M PaderoTheodore C Friedman
Mar 28, 2002·Thyroid : Official Journal of the American Thyroid Association·G BrentaM A Pisarev
Oct 16, 2003·Thyroid : Official Journal of the American Thyroid Association·Richard HamplKarel Vondra
Apr 22, 1999·Thyroid : Official Journal of the American Thyroid Association·G BrentaM A Pisarev
Sep 25, 2012·Human Reproduction·M Ángeles Martínez-GarcíaHéctor F Escobar-Morreale
Apr 5, 2012·The Journal of Clinical Endocrinology and Metabolism·Ali IranmaneshJohannes D Veldhuis
Jan 18, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Marijke ReyndersJohan Smitz
Feb 25, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Markus ThalerPeter B Luppa
Nov 6, 2013·International Journal of Environmental Research and Public Health·Hye Ah LeeHyesook Park
Apr 8, 2014·Endocrine·Andrea SansoneAndrea Lenzi
Mar 29, 2008·The Journal of Sexual Medicine·Andrea SaloniaFrancesco Montorsi
Oct 28, 2008·Fertility and Sterility·Ricardo AzzizUNKNOWN Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Mar 1, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Mahder Seifu ManendaRong Shi
Jun 19, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Charles E Schwartz, Roger E Stevenson
Nov 3, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Markus A ThalerPeter B Luppa
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Amanda M ShearmanDouglas P Kiel
Feb 11, 2011·Diabetes/metabolism Research and Reviews·Maritta Pöyhönen-AlhoR Kaaja
Jun 14, 2012·The Journal of Obstetrics and Gynaecology Research·Bin LiuZi-Lian Wang
May 23, 2012·The Journal of Obstetrics and Gynaecology Research·Gamze S CaglarSelda Demirtaş
Sep 11, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Ruggero DittadiMassimo Gion
Jun 6, 2015·Trends in Endocrinology and Metabolism : TEM·Rafael SimóDavid M Selva
Jan 1, 2010·Hormone Molecular Biology and Clinical Investigation·Ludmila ZamrazilováRichard Hampl
Apr 17, 2001·American Journal of Obstetrics and Gynecology·J L BarthaR Comino-Delgado
Feb 7, 2018·Clinical Endocrinology·Brian G KeevilJean-Marc Kaufman
Mar 26, 2004·The Prostate·Nagi B KumarJulio Pow-Sang
Mar 9, 2018·Endocrine Connections·Mikkel AndreassenNiels Jørgensen
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·K K Miller
Apr 8, 2020·Experimental and Therapeutic Medicine·Chen-Yun MiaoQin Zhang
Jan 5, 2011·The Journal of Clinical Endocrinology and Metabolism·Eleni KandarakiEvanthia Diamanti-Kandarakis
Nov 25, 2004·Endocrine Reviews·Héctor F Escobar-MorrealeJosé L San Millán

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