Clinical utility of soluble interleukin-2 receptor in hemophagocytic syndromes: a systematic scoping review

Annals of Hematology
Molly LinLuke Y C Chen

Abstract

The serum-soluble interleukin-2 receptor (sIL-2r) level is considered an important diagnostic test and disease marker in hemophagocytic syndromes/hemophagocytic lymphohistiocytosis (HPS/HLH). However, this cytokine receptor is rarely measured in clinical practice and has been excluded from recent diagnostic/classification criteria such as the HScore and macrophage activation syndrome (MAS) 16. We performed a systematic scoping review of 64 articles (1975-2016) examining the clinical utility of sIL-2r in HPS/HLH. Twenty-two articles describe sIL-2r as a sensitive diagnostic marker for HLH, but only three distinct datasets actually address sensitivity. The original HLH-2004 Guidelines reported sensitivity of 93% and specificity of 100% for sIL-2r ≥ 2400, based on a pediatric dataset (n = 152) which is published for the first time in this review. Two pediatric studies reported sensitivity of 89% for sIL-2r ≥ 2400 in diagnosis of MAS complicating juvenile idiopathic arthritis (JIA) (n = 27) and 88% for secondary HLH in acute liver failure (n = 9). Twenty articles described sIL-2r as a dynamic marker of disease activity that falls with response to treatment, and 15 described high initial sIL-2r levels >10,000 U/mL as a poor prognost...Continue Reading

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Citations

Sep 29, 2017·Current Opinion in Allergy and Clinical Immunology·Christian A Wysocki
Sep 12, 2018·British Journal of Haematology·Luke Y C ChenAndre Mattman
Sep 1, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Shunzong YuanShiping Song
Jan 4, 2018·Blood Advances·Anna HaydenLuke Y C Chen
Jun 4, 2019·AACN Advanced Critical Care·Janice SkinnerBrenda K Shelton
Sep 3, 2019·The Journal of Rheumatology·Alicia Rodriguez-PlaUNKNOWN Vasculitis Clinical Research Consortium
Nov 6, 2018·Journal of Intensive Care Medicine·Virginie LemialeEric Mariotte
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Sep 16, 2020·International Journal of Clinical Practice·Jun ZhouHua-Guo Xu
May 20, 2020·Blood Reviews·James T EnglandLuke Y C Chen
Feb 7, 2021·Nature Reviews. Rheumatology·Dennis McGonagleCharlie Bridgewood
Dec 12, 2020·Journal of the Chinese Medical Association : JCMA·Wei-Yu KaoWeu Wang
Mar 9, 2021·International Journal of Hematology·Masayuki NagasawaTomohiro Morio
Feb 10, 2021·Blood Reviews·James T EnglandLuke Y C Chen
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Jan 30, 2020·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·Eric McGinnisMichelle P Wong
Mar 17, 2020·Critical Care Clinics·Sandrine ValadeElie Azoulay

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