Clinical utility of the 70-gene MammaPrint profile in a Japanese population

Japanese Journal of Clinical Oncology
Makoto IshitobiKikuya Kato

Abstract

van't Veer and colleagues developed a 70-gene prognosis profile known as MammaPrint to identify breast cancer patients who were at low risk of developing metastases. We evaluated the prognostic value of the 70-gene MammaPrint profile in Japanese women with node-negative breast cancer. Frozen tumour samples from 102 eligible node-negative breast cancer patients aged 70 or younger were characterized with the MammaPrint array. The patients were treated with breast-conserving therapy or mastectomy with axillary lymph node dissection between December 1998 and August 2001. About 73 percent received adjuvant hormonal therapy and 28 percent received adjuvant chemotherapy. The gene expression profiles obtained by MammaPrint classified the patients as high- or low-genomic risk. The median follow-up was 7.1 years. Among the 102 patients, 20 (20%) were classified as low-genomic risk and 82 (80%) were classified as high-genomic risk. The probability of distant metastasis-free survival at five years was 100% for the low-risk group and 94% for the high-risk group. The 70-gene MammaPrint prognosis profile accurately identified Japanese breast cancer patients at low risk of developing recurrences. In fact, 100% of the individuals in the low-ris...Continue Reading

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Citations

Oct 1, 2014·Journal of the National Cancer Institute·Nicolas BakindeAbiola Ibraheem
Feb 24, 2015·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yasuto Naoi, Shinzaburo Noguchi
Jan 1, 2014·The Journal of Molecular Diagnostics : JMD·Anna SapinoCharles E Cox
Dec 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ellen G EngelhardtAnne M Stiggelbout
Aug 30, 2018·Future Oncology·Mariana BrandãoMartine Piccart-Gebhart
Jul 19, 2012·Journal of breast cancer·Woojae KimRae Woong Park
Aug 19, 2011·Journal of breast cancer·Kuk Young NaYong Sik Jung
Jun 9, 2020·JCO Global Oncology·Gouri Shankar BhattacharyyaS P Somashekhar
Nov 1, 2013·Personalized Medicine·Leonie Jm DelahayeAnnuska M Glas
Feb 24, 2019·Breast Cancer Research and Treatment·R WuerstleinUNKNOWN WSG-PRIMe investigators in Germany, Austria, Switzerland
Apr 25, 2015·The International Journal of Biological Markers·Minako SakuraiHironobu Sasano

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