Clinical utility of the platelet function analyzer (PFA-100) for the assessment of the platelet status in patients with congestive heart failure (EPCOT trial)

Thrombosis Research
V L SerebruanyC M O'Connor

Abstract

Data from small studies have shown the presence of platelet abnormalities in patients with congestive heart failure (CHF). We sought to characterize the diagnostic utility of platelet function analyzer (PFA-100) in the CHF population. Blood samples were obtained for measurement of adenosine diphosphate (ADP)/collagen and epinephrine/collagen shear-induced closure time (CT), whole blood aggregation, platelet contractile force, activity of glycoprotein (GP) IIb/IIIa, and P-selectin receptors in 100 consecutive outpatients with CHF. Substantial interindividual variability of platelet characteristics exists in patients with CHF. There were no statistically significant differences when patients were divided by the incidence of vascular events, emergency revascularization needs, survival, or etiology of heart failure. Aspirin use did not affect instrument readings as well. CT correlates well with whole blood aggregometry (r(2)=.587) and less with GP IIb/IIIa activity (r(2)=.326). No correlation has been observed for the CT with the platelet-bound P-selectin (r(2)=.041) and platelet contractile force measures (r(2)=.028). PFA-100 is indeed capable to serve as a platelet analyzer and may be successfully used as a screening device. Howe...Continue Reading

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Citations

May 3, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Margaret L RandMarian A Packham
Aug 13, 2002·Current Opinion in Hematology·Emmanuel J Favaloro
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Irena Preloznik ZupanPeter Cernelc
Oct 8, 2003·Journal of Veterinary Internal Medicine·Inge TarnowHenrik D Pedersen
Feb 9, 2007·Thrombosis Research·Irene ChungGregory Y H Lip
Jul 18, 2007·Perfusion·Chad W SmithDavid P Webb
Nov 1, 2015·Journal of Cardiovascular Pharmacology and Therapeutics·Nadezhda GlezevaMark Ledwidge

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